The evolution, diversity, and host associations of rhabdoviruses

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

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The evolution, diversity, and host associations of rhabdoviruses. / Longdon, Ben; Murray, Gemma G R; Palmer, William J et al.
Yn: Virus Evolution, Cyfrol 1, Rhif 1, vev014, 01.03.2015.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

Longdon, B, Murray, GGR, Palmer, WJ, Day, JP, Parker, DJ, Welch, JJ, Obbard, DJ & Jiggins, FM 2015, 'The evolution, diversity, and host associations of rhabdoviruses', Virus Evolution, cyfrol. 1, rhif 1, vev014. https://doi.org/10.1093/ve/vev014

APA

Longdon, B., Murray, G. G. R., Palmer, W. J., Day, J. P., Parker, D. J., Welch, J. J., Obbard, D. J., & Jiggins, F. M. (2015). The evolution, diversity, and host associations of rhabdoviruses. Virus Evolution, 1(1), Erthygl vev014. https://doi.org/10.1093/ve/vev014

CBE

Longdon B, Murray GGR, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM. 2015. The evolution, diversity, and host associations of rhabdoviruses. Virus Evolution. 1(1):Article vev014. https://doi.org/10.1093/ve/vev014

MLA

VancouverVancouver

Longdon B, Murray GGR, Palmer WJ, Day JP, Parker DJ, Welch JJ et al. The evolution, diversity, and host associations of rhabdoviruses. Virus Evolution. 2015 Maw 1;1(1):vev014. Epub 2015 Ion 1. doi: 10.1093/ve/vev014

Author

Longdon, Ben ; Murray, Gemma G R ; Palmer, William J et al. / The evolution, diversity, and host associations of rhabdoviruses. Yn: Virus Evolution. 2015 ; Cyfrol 1, Rhif 1.

RIS

TY - JOUR

T1 - The evolution, diversity, and host associations of rhabdoviruses

AU - Longdon, Ben

AU - Murray, Gemma G R

AU - Palmer, William J

AU - Day, Jonathan P

AU - Parker, Darren J

AU - Welch, John J

AU - Obbard, Darren J

AU - Jiggins, Francis M

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Metagenomic studies are leading to the discovery of a hidden diversity of RNA viruses. These new viruses are poorly characterized and new approaches are needed predict the host species these viruses pose a risk to. The rhabdoviruses are a diverse family of RNA viruses that includes important pathogens of humans, animals, and plants. We have discovered thirty-two new rhabdoviruses through a combination of our own RNA sequencing of insects and searching public sequence databases. Combining these with previously known sequences we reconstructed the phylogeny of 195 rhabdovirus sequences, and produced the most in depth analysis of the family to date. In most cases we know nothing about the biology of the viruses beyond the host they were identified from, but our dataset provides a powerful phylogenetic approach to predict which are vector-borne viruses and which are specific to vertebrates or arthropods. By reconstructing ancestral and present host states we found that switches between major groups of hosts have occurred rarely during rhabdovirus evolution. This allowed us to propose seventy-six new likely vector-borne vertebrate viruses among viruses identified from vertebrates or biting insects. Based on currently available data, our analysis suggests it is likely there was a single origin of the known plant viruses and arthropod-borne vertebrate viruses, while vertebrate- and arthropod-specific viruses arose at least twice. There are also few transitions between aquatic and terrestrial ecosystems. Viruses also cluster together at a finer scale, with closely related viruses tending to be found in closely related hosts. Our data therefore suggest that throughout their evolution, rhabdoviruses have occasionally jumped between distantly related host species before spreading through related hosts in the same environment. This approach offers a way to predict the most probable biology and key traits of newly discovered viruses.

AB - Metagenomic studies are leading to the discovery of a hidden diversity of RNA viruses. These new viruses are poorly characterized and new approaches are needed predict the host species these viruses pose a risk to. The rhabdoviruses are a diverse family of RNA viruses that includes important pathogens of humans, animals, and plants. We have discovered thirty-two new rhabdoviruses through a combination of our own RNA sequencing of insects and searching public sequence databases. Combining these with previously known sequences we reconstructed the phylogeny of 195 rhabdovirus sequences, and produced the most in depth analysis of the family to date. In most cases we know nothing about the biology of the viruses beyond the host they were identified from, but our dataset provides a powerful phylogenetic approach to predict which are vector-borne viruses and which are specific to vertebrates or arthropods. By reconstructing ancestral and present host states we found that switches between major groups of hosts have occurred rarely during rhabdovirus evolution. This allowed us to propose seventy-six new likely vector-borne vertebrate viruses among viruses identified from vertebrates or biting insects. Based on currently available data, our analysis suggests it is likely there was a single origin of the known plant viruses and arthropod-borne vertebrate viruses, while vertebrate- and arthropod-specific viruses arose at least twice. There are also few transitions between aquatic and terrestrial ecosystems. Viruses also cluster together at a finer scale, with closely related viruses tending to be found in closely related hosts. Our data therefore suggest that throughout their evolution, rhabdoviruses have occasionally jumped between distantly related host species before spreading through related hosts in the same environment. This approach offers a way to predict the most probable biology and key traits of newly discovered viruses.

U2 - 10.1093/ve/vev014

DO - 10.1093/ve/vev014

M3 - Article

C2 - 27774286

VL - 1

JO - Virus Evolution

JF - Virus Evolution

SN - 2057-1577

IS - 1

M1 - vev014

ER -