Fersiynau electronig

Dangosydd eitem ddigidol (DOI)

  • Ali Kermanizadeh
    University of Copenhagen
  • Caroline Chauché
  • David M Brown
  • Steffen Loft
  • Peter Møller

The terms oxidative stress, free radical generation, and intracellular antioxidant protection have become part of everyday nanotoxicology terminology. In recent years, an ever increasing number of in vitro and in vivo studies have implicated disruptions to the redox balance and oxidative stress as one of the main contributors to nanomaterial (NM) induced adverse effects. One of the most important and widely investigated of these effects is genotoxicity. In general, systems that defend an organism against oxidative damage to DNA are very complex and include prevention of reactive oxygen species (ROS) production, neutralizing ROS (scavengers), enzymatic nucleotide pool sanitation, and DNA repair. This review discusses the importance of the maintenance of the redox balance in this context before examining studies that have investigated engineered NM induced redox imbalance and genotoxicity. Furthermore, we identify data gaps, and highlight a number of issues that exist with the methodologies that are routinely utilized to investigate intracellular ROS production or anti-oxidant depletion. We conclude that for a large number of engineered NM types changes in the redox balance toward oxidative stress are normally associated with DNA damage.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)111-24
Nifer y tudalennau14
CyfnodolynEnvironmental and molecular mutagenesis
Cyfrol56
Rhif y cyfnodolyn2
Dyddiad ar-lein cynnar26 Tach 2014
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - Maw 2015
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau