TY - JOUR

T1 - Vascular function and inflammation in rheumatoid arthritis

T2 - the role of physical activity

AU - Metsios, George S

AU - Stavropoulos-Kalinoglou, Antonios

AU - Sandoo, Aamer

AU - van Zanten, Jet J C S Veldhuijzen

AU - Toms, Tracey E

AU - John, Holly

AU - Kitas, George D

PY - 2010/2/23

Y1 - 2010/2/23

N2 - Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.

AB - Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction - atherosclerosis network.

KW - Journal Article

U2 - 10.2174/1874192401004020089

DO - 10.2174/1874192401004020089

M3 - Article

C2 - 20361002

VL - 4

SP - 89

EP - 96

JO - The open cardiovascular medicine journal

JF - The open cardiovascular medicine journal

SN - 1874-1924

ER -