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Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

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Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels. / Xu, Qian; Venet, Manon; WAng, Wei et al.
Yn: ACS Applied materials and interfaces, Cyfrol 10, Rhif 46, 30.10.2018, t. 39494-39504.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

HarvardHarvard

Xu, Q, Venet, M, WAng, W, Creagh-Flynn, J, Wang, X, Li, X, Gao, Y, Zhou, D, Zeng, M, Lara-Saez, I, A, S, Tai, H & Wang, W 2018, 'Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels', ACS Applied materials and interfaces, cyfrol. 10, rhif 46, tt. 39494-39504. https://doi.org/10.1021/acsami.8b15006

APA

Xu, Q., Venet, M., WAng, W., Creagh-Flynn, J., Wang, X., Li, X., Gao, Y., Zhou, D., Zeng, M., Lara-Saez, I., A, S., Tai, H., & Wang, W. (2018). Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels. ACS Applied materials and interfaces, 10(46), 39494-39504. https://doi.org/10.1021/acsami.8b15006

CBE

Xu Q, Venet M, WAng W, Creagh-Flynn J, Wang X, Li X, Gao Y, Zhou D, Zeng M, Lara-Saez I, et al. 2018. Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels. ACS Applied materials and interfaces. 10(46):39494-39504. https://doi.org/10.1021/acsami.8b15006

MLA

Xu, Qian et al. "Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels". ACS Applied materials and interfaces. 2018, 10(46). 39494-39504. https://doi.org/10.1021/acsami.8b15006

VancouverVancouver

Xu Q, Venet M, WAng W, Creagh-Flynn J, Wang X, Li X et al. Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels. ACS Applied materials and interfaces. 2018 Hyd 30;10(46):39494-39504. doi: 10.1021/acsami.8b15006

Author

Xu, Qian ; Venet, Manon ; WAng, Wei et al. / Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels. Yn: ACS Applied materials and interfaces. 2018 ; Cyfrol 10, Rhif 46. tt. 39494-39504.

RIS

TY - JOUR

T1 - Versatile Hyperbranched Poly(β-Hydrazide Ester) Macromers as Injectable Antioxidative Hydrogels

AU - Xu, Qian

AU - Venet, Manon

AU - WAng, Wei

AU - Creagh-Flynn, Jack

AU - Wang, Xi

AU - Li, Xiaolin

AU - Gao, Yongshenng

AU - Zhou, Dezhong

AU - Zeng, Ming

AU - Lara-Saez, Irene

AU - A, Sigen

AU - Tai, Hongyun

AU - Wang, Wenxin

PY - 2018/10/30

Y1 - 2018/10/30

N2 - Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

AB - Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regu-lating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a se-ries of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an “A2+B4” Michael addition approach. The three-dimensional structure of HB-PBHEs with multi-acrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via crosslinking with thiolated hyaluronic acid, and (2) robust UV-crosslinked hydrogels. The disulfide containing macromers and hydrogels exhibit H2O2-responsive degradation compared to the counterparts synthesized by a dihydrazide monomer without disulfide moieties. The cell via-bility under a high ROS environment can be well-maintained under the protection of the disulfide containing hydrogels.

U2 - 10.1021/acsami.8b15006

DO - 10.1021/acsami.8b15006

M3 - Article

VL - 10

SP - 39494

EP - 39504

JO - ACS Applied materials and interfaces

JF - ACS Applied materials and interfaces

SN - 1944-8244

IS - 46

ER -