Under the leadership of Bangor University’s Professor Dean Williams, the vascular surgery department at Ysbyty Gwynedd Hospital introduced a research-verified novel approach to the management of patient-groups at risk of lower-limb amputation (e.g. diabetics, rheumatoid arthritis sufferers and intravenous drug users). This rapid-access multidisciplinary clinical-care model led to a significant and sustained decrease in lower-limb amputation rate (over 95% and over 80% reduction, respectively, for diabetic and non-diabetic patients; regional population level). Wider impact was demonstrated by the inclusion of key research citations in national (NICE Diabetic foot guidelines 2015) and international guidelines. The Bangor-developed clinical-care model has informed clinical best-practice of vascular surgeons via Williams’ overseas fellowship schemes and international conference presentations. Williams also plays a critical advisory role for NHS Digital, auditing UK diabetic foot-care for NICE guideline compliance.