Research Portal

Dr Andrew Pierce

Lecturer (Teaching & Research)

Affiliations

ORCID: 0000-0001-5995-2469

Contact info

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

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  1. Article › Research › Peer-reviewed

  2. A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Dec 2014, In: Bioinformatics. p. 549-558

    Research output: Contribution to journal › Article › peer-review

  3. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, In: Blood. p. 1716-1723

    Research output: Contribution to journal › Article › peer-review

  4. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Oct 2013, In: Leukemia. 27, p. 932-940

    Research output: Contribution to journal › Article › peer-review

  5. Published

    A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    AJ, W., A, P., E, J., C, Z., M, A-OD., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Nov 2013, In: Molecular and Cellular Proteomics. 3319 p.

    Research output: Contribution to journal › Article › peer-review

  6. AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Apr 2019, In: HemaSphere.

    Research output: Contribution to journal › Article › peer-review

  7. Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, In: Cell Death and Disease. 8, 6, p. e2875-e2875

    Research output: Contribution to journal › Article › peer-review

  8. Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.

    CA, E., Pierce, A., SA, W., E, S., CM, H. & AD, W., 1 Sept 1999, In: Blood. 94, 5, p. 1504-1514

    Research output: Contribution to journal › Article › peer-review

  9. An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.

    Pierce, A., CM, H., SE, N., E, S., TM, D., JM, L., PJ, O-L., G, W. & AD, W., 23 Mar 1998, In: Journal of Cell Biology. 140, 6, p. 1511-1518

    Research output: Contribution to journal › Article › peer-review

  10. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

    M, A-OD., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, In: Natur Protocols.

    Research output: Contribution to journal › Article › peer-review

  11. Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

    CF, L., S, G., E, R-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Sept 2010, In: Proteomics. 10, 18, p. 3321-3342

    Research output: Contribution to journal › Article › peer-review

  12. BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

    Pierce, A., E, S., S, A. & AD, W., 2002, In: Oncogene. 21, p. 3068-3075

    Research output: Contribution to journal › Article › peer-review

  13. BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Jun 2012, In: Journal of Proteomics. 77, p. 14-26

    Research output: Contribution to journal › Article › peer-review

  14. Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.

    Pierce, A., E, S., S, W., C, D., JM, F., J, M., PJ, O-L., TM, D. & AD, W., 16 Nov 2000, In: Oncogene. 19, p. 5487-5497

    Research output: Contribution to journal › Article › peer-review

  15. Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

    D, X., Pierce, A., N, U-D., AD, W. & PJ, O-L., Feb 2004, In: Cellular Signalling. 16, 2, p. 145-156

    Research output: Contribution to journal › Article › peer-review

  16. Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Nov 2002, In: Molecular and Cellular Proteomics. 1, 11, p. 876-884

    Research output: Contribution to journal › Article › peer-review

  17. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Aug 2005, In: Leukemia. p. 1851-1853

    Research output: Contribution to journal › Article › peer-review

  18. Published

    Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells

    Pearson, S., D. Whitton, A. & Pierce, A., 31 Mar 2022, In: PLoS ONE. 17, 3, 11 p., e0266298.

    Research output: Contribution to journal › Article › peer-review

  19. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 May 2004, In: Blood. p. 3751-3759

    Research output: Contribution to journal › Article › peer-review

  20. Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Jul 2021, In: Cancers.

    Research output: Contribution to journal › Article › peer-review

  21. Correction: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)

    Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, In: PLoS ONE. 8, 6

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover

    Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Apr 2024, In: eBioMedicine. 102, p. 105064

    Research output: Contribution to journal › Article › peer-review

  23. Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

  24. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

    Pierce, A., Y, L., HG, H., S, T., PJ, O-L., AD, W. & E, S., 31 Mar 2006, In: British Journal of Haematology. 133, 3, p. 345-352

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

    SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, In: Nature. 534, p. 341-346

    Research output: Contribution to journal › Article › peer-review

  26. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

    PA, C., EJ, C., M, A-OD., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, In: BMJ Open Respiratory Research.

    Research output: Contribution to journal › Article › peer-review

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