Research Portal

Dr Andrew Pierce

Lecturer (Teaching & Research)

Affiliations

ORCID: 0000-0001-5995-2469

Contact info

Location: Brambell, Room 412

Email: a.pierce@bangor.ac.uk

Current Position: Lecturer, Medical and Health Sciences

Other external Positions: Honorary Lecturer, Division of Cancer Sciences, The University of Manchester

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  1. Article › Research › Peer-reviewed

  2. A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data.

    C, Z., MJ, W., AJ, W., A, P., C, B., C, D. & AD, W., 15 Dec 2014, In: Bioinformatics. p. 549-558

    Research output: Contribution to journal › Article › peer-review

  3. A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation.

    L, M., S, P., N, P., B, P., A, P., AD, W. & AE, I., 2006, In: Blood. p. 1716-1723

    Research output: Contribution to journal › Article › peer-review

  4. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

    F, G., A, P., MB, G. S., M, S., SA, A., TL, H., DD, T., T, T. & AD, W., 3 Oct 2013, In: Leukemia. 27, p. 932-940

    Research output: Contribution to journal › Article › peer-review

  5. Published

    A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    AJ, W., A, P., E, J., C, Z., M, A-OD., L, L., RD, U., SA, A., MJ, W., S, C., E, S., TL, H. & AD, W., 1 Nov 2013, In: Molecular and Cellular Proteomics. 3319 p.

    Research output: Contribution to journal › Article › peer-review

  6. AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

    Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Apr 2019, In: HemaSphere.

    Research output: Contribution to journal › Article › peer-review

  7. Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

    Meyer, S., Stevens, A., Paredes, R., Schneider, M., Walker, M. J., Williamson, A. J. K., Gonzalez-Sanchez, M-B., Smetsers, S., Dalal, V., Teng, H. Y., White, D. J., Taylor, S., Muter, J., Pierce, A., de Leonibus, C., Rockx, D. A. P., Rooimans, M. A., Spooncer, E., Stauffer, S., Biswas, K., Godthelp, B., Dorsman, J., Clayton, P. E., Sharan, S. K. & Whetton, A. D., 2017, In: Cell Death and Disease. 8, 6, p. e2875-e2875

    Research output: Contribution to journal › Article › peer-review

  8. Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development.

    CA, E., Pierce, A., SA, W., E, S., CM, H. & AD, W., 1 Sept 1999, In: Blood. 94, 5, p. 1504-1514

    Research output: Contribution to journal › Article › peer-review

  9. An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events.

    Pierce, A., CM, H., SE, N., E, S., TM, D., JM, L., PJ, O-L., G, W. & AD, W., 23 Mar 1998, In: Journal of Cell Biology. 140, 6, p. 1511-1518

    Research output: Contribution to journal › Article › peer-review

  10. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

    M, A-OD., Pierce, A., F, P., AJ, W., MT, S., MJ, W., TL, H. & AD, W., 2015, In: Natur Protocols.

    Research output: Contribution to journal › Article › peer-review

  11. Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches.

    CF, L., S, G., E, R-S., A, P., RD, U., E, J., CA, E., S, J. G. & AD, W., 2 Sept 2010, In: Proteomics. 10, 18, p. 3321-3342

    Research output: Contribution to journal › Article › peer-review

  12. BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor.

    Pierce, A., E, S., S, A. & AD, W., 2002, In: Oncogene. 21, p. 3068-3075

    Research output: Contribution to journal › Article › peer-review

  13. BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response.

    F, G., AJ, W., S, T., DN, P., E, S., A, P. & AD, W., 12 Jun 2012, In: Journal of Proteomics. 77, p. 14-26

    Research output: Contribution to journal › Article › peer-review

  14. Bcr-Abl protein tyrosine kinase activity induces a loss of p53 protein that mediates a delay in myeloid differentiation.

    Pierce, A., E, S., S, W., C, D., JM, F., J, M., PJ, O-L., TM, D. & AD, W., 16 Nov 2000, In: Oncogene. 19, p. 5487-5497

    Research output: Contribution to journal › Article › peer-review

  15. Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII.

    D, X., Pierce, A., N, U-D., AD, W. & PJ, O-L., Feb 2004, In: Cellular Signalling. 16, 2, p. 145-156

    Research output: Contribution to journal › Article › peer-review

  16. Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

    DL, S., CA, E., A, P., SJ, G. & AD, W., 1 Nov 2002, In: Molecular and Cellular Proteomics. 1, 11, p. 876-884

    Research output: Contribution to journal › Article › peer-review

  17. Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

    HG, H., Pierce, A., WA, S., C, P. D., A, G., A, I., E, S. & AD, W., 18 Aug 2005, In: Leukemia. p. 1851-1853

    Research output: Contribution to journal › Article › peer-review

  18. Published

    Combination of curaxin and tyrosine kinase inhibitors display enhanced killing of primitive Chronic Myeloid Leukaemia cells

    Pearson, S., D. Whitton, A. & Pierce, A., 31 Mar 2022, In: PLoS ONE. 17, 3, 11 p., e0266298.

    Research output: Contribution to journal › Article › peer-review

  19. Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility.

    CA, E., R, T., D, B., A, P., J, S., Y, L., HG, H., A, G., CP, D., SJ, G., E, S. & AD, W., 15 May 2004, In: Blood. p. 3751-3759

    Research output: Contribution to journal › Article › peer-review

  20. Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

    Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Jul 2021, In: Cancers.

    Research output: Contribution to journal › Article › peer-review

  21. Correction: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)

    Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 2012, In: PLoS ONE. 8, 6

    Research output: Contribution to journal › Article › peer-review

  22. Published

    Detection of endometrial cancer in cervico-vaginal fluid and blood plasma: Leveraging proteomics and machine learning for biomarker discover

    Njoku, K., Pierce, A., Chiasserini, D., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Geifman, N., Whetton, A. D. & Crosbie, E. J., Apr 2024, In: eBioMedicine. 102, p. 105064

    Research output: Contribution to journal › Article › peer-review

  23. Development of a selected reaction monitoring mass spectrometry-based assay to detect asparaginyl endopeptidase activity in biological fluids.

    A, D., DN, P., MJ, W., OJ, G., C, P., M, H., AJ, W., Pierce, A., A, P., RD, U., S, K., V, S. & AD, W., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

  24. Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation.

    Pierce, A., Y, L., HG, H., S, T., PJ, O-L., AD, W. & E, S., 31 Mar 2006, In: British Journal of Haematology. 133, 3, p. 345-352

    Research output: Contribution to journal › Article › peer-review

  25. Published

    Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells.

    SA, A., LE, H., E, C., ME, D., K, D., AJ, W., K, K., P, B., LE, P., MT, S., F, P., Pierce, A., M, C., C, N., SM, G., D, V., AD, W. & TL, H., 2016, In: Nature. 534, p. 341-346

    Research output: Contribution to journal › Article › peer-review

  26. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

    PA, C., EJ, C., M, A-OD., M, W., R, H., M, P., R, S., L, J., R, B., A, P. & AD, W., 2016, In: BMJ Open Respiratory Research.

    Research output: Contribution to journal › Article › peer-review

  27. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

    Paredes, R., Schneider, M., Stevens, A., White, D. J., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J. R., Connors, K., Wiseman, D. H., Chadwick, J. A., Löffler, H., Teng, H. Y., Lovell, S., Unwin, R., van de Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T. C. P., Pierce, A., Whetton, A. D. & Meyer, S., 1 Jun 2018, In: Nucleic Acids Research. 46, 15, p. 7662-7674 13 p.

    Research output: Contribution to journal › Article › peer-review

  28. EVI1 oncoprotein expression and CtBP1-association oscillate through the cell cycle

    Paredes, R., Schneider, M., Pearson, S., Teng, H. Y., Kelly, J. R., Pierce, A., Somervaille, T. C. P., Whetton, A. D. & Meyer, S., 2020, In: Molecular Biology Reports. 47, 10, p. 8293-8300 8 p.

    Research output: Contribution to journal › Article › peer-review

  29. EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

    Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A. & Meyer, S., 20 Oct 2020, In: Cell Death and Disease. 11

    Research output: Contribution to journal › Article › peer-review

  30. Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line.

    Pierce, A., AD, W., PJ, O-L., J, T., E, S., TM, D. & CM, H., 15 Mar 1998, In: Journal of Cell Science. p. 815-823

    Research output: Contribution to journal › Article › peer-review

  31. Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases.

    Pierce, A., RD, U., CA, E., S, G., L, C., L, Z., E, J., CF, L., D, B., MJ, O., CJ, M., DA, B., E, S. & AD, W., 1 May 2008, In: Molecular and Cellular Proteomics. 7, 5, p. 853-863

    Research output: Contribution to journal › Article › peer-review

  32. Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate.

    C, L., CA, E., E, S., A, P., R, M. & AD, W., 3 Sept 2003, In: British Journal of Haematology. 122, 6, p. 985-995

    Research output: Contribution to journal › Article › peer-review

  33. Published

    Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

    RD, U., DW, S., Y, L., A, P., DG, G. & AD, W., Feb 2005, In: Journal of Biological Chemistry. 280, 8, p. 6316-6326

    Research output: Contribution to journal › Article › peer-review

  34. Published

    HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

    Maiques-Diaz, A., Nicosia, L., Basma, N. J., Romero-Camarero, I., Camera, F., Spencer, G. J., Amaral, F. M. R., Simeoni, F., Wingelhofer, B., Williamson, A. J. K., Pierce, A., Whetton, A. D. & Somervaille, T. C. P., 28 Oct 2022, In: Oncogene. 41, 44, p. 4841-4854 14 p.

    Research output: Contribution to journal › Article › peer-review

  35. Haemopoietic growth factors and leukaemogenesis.

    Pierce, A. & AD, W., 1 May 1997, In: Biochemical Society Transactions. 25, 2, p. 366-370

    Research output: Contribution to journal › Article › peer-review

  36. Identification of curaxin as a potential new therapeutic for JAK2 V617F mutant patients

    Pearson, S., Blance, R., Yan, F., Hsieh, Y-C., Geary, B., Amaral, F. M. R., Somervaille, T. C. P., Kirschner, K., Whetton, A. D. & Pierce, A., 30 May 2023, In: PLoS ONE. 18, 5, 16 p., 0286412.

    Research output: Contribution to journal › Article › peer-review

  37. Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors.

    CA, E., S, A., A, P. & AD, W., 1 Nov 2002, In: Blood. 100, 9, p. 3164-3174

    Research output: Contribution to journal › Article › peer-review

  38. Published

    Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia

    Alanazi, B., Munje, C. R., Rastogi, N., Williamson, A. J. K., Taylor, S., Hole, P. S., Hodges, M., Doyle, M., Baker, S., Gilkes, A. F., Knapper, S., Pierce, A., Whetton, A. D., Darley, R. L. & Tonks, A., 2020, In: Leukemia. 34, 2, p. 427-440 14 p.

    Research output: Contribution to journal › Article › peer-review

  39. Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1.

    AD, W., Y, L., A, P., L, C. & E, S., 15 Oct 2003, In: Blood. 102, 8, p. 2798-2802

    Research output: Contribution to journal › Article › peer-review

  40. MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

    AD, W., NC, A., S, P., E, J., L, Z., R, B., AC, K., A, N., S, T., AJ, W. & A, P., 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

  41. Published

    Macrophage inflammatory protein-1 alpha receptors are present on cells enriched for CD34 expression from patients with chronic myeloid leukemia.

    RC, C., GS, L., PJ, O-L., A, P. & AD, W., 1 Dec 1995, In: Blood. 86, 11, p. 4270-4277

    Research output: Contribution to journal › Article › peer-review

  42. Metabolomic Biomarkers for the Detection of Obesity-Driven Endometrial Cancer

    Njoku, K., Campbell, A. E., Geary, B., MacKintosh, M. L., Derbyshire, A. E., Kitson, S. J., Sivalingam, V. N., Pierce, A., Whetton, A. D. & Crosbie, E. J., 10 Feb 2021, In: Cancers. 13, 4, p. 718 1 p.

    Research output: Contribution to journal › Article › peer-review

  43. Molecular cloning of the major cell surface heparan sulfate proteoglycan from rat liver.

    Pierce, A., M, L., IN, H., GJ, C. & JT, G., 25 Feb 1992, In: Journal of Biological Chemistry. 267, 6, p. 3894-3900

    Research output: Contribution to journal › Article › peer-review

  44. Oncogenic MYC amplifies mitotic perturbations

    Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Aug 2019, In: Open Biology.

    Research output: Contribution to journal › Article › peer-review

  45. Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

    DJ, W., RD, U., E, B., A, P., HY, T., J, M., B, G., TD, S., J, G., S, L., TC, S., R, D., AD, W. & S, M., 12 Jun 2013, In: PLoS ONE.

    Research output: Contribution to journal › Article › peer-review

  46. Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.

    S, P., AJK, W., R, B., TCP, S., S, T., N, A., AD, W. & A, P., 1 Dec 2017, In: Leukemia. 31

    Research output: Contribution to journal › Article › peer-review

  47. Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

    Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, In: Journal of Proteome Research.

    Research output: Contribution to journal › Article › peer-review

  48. Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFR activation of the interferon response pathways.

    E, D., C, G., RW, F., RD, U., JR, G., A, P., AD, W. & H, W., Nov 2010, In: Stem Cell Research. 5, 3, p. 226-243

    Research output: Contribution to journal › Article › peer-review

  49. Published

    Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women

    Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da Sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 18 May 2023, In: British Journal of Cancer. 128, 9, p. 1723-1732 10 p.

    Research output: Contribution to journal › Article › peer-review

  50. Published

    Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells.

    Pierce, A., RD, U., A, P., RB, W., DW, S. & AD, W., 1 Jul 2005, In: Molecular and Cellular Proteomics. 4, 7

    Research output: Contribution to journal › Article › peer-review

  51. Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells.

    RD, U., DL, S., D, B., CL, W., CJ, M., CA, E., E, J., SA, B., K, B., A, P., E, S. & AD, W., 15 Jun 2006, In: Blood. 107, 12, p. 4687-4694

    Research output: Contribution to journal › Article › peer-review

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