Professor Dyfrig Hughes

Athro mewn Ffarmacoeconomeg / Cyfarwyddwr Ymchwil

  1. Published

    Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout

    Hill McManus, D., Marshall, S., Soto, E. & Hughes, D., Sept 2019, In: Clinical Pharmacology and Therapeutics. 106, 3, p. 652-660

    Research output: Contribution to journalArticlepeer-review

  2. Published

    Combining model-based clinical trial simulation, pharmacoeconomics and value of information to optimize trial design

    Hill-McManus, D. & Hughes, D., Jan 2021, In: CPT: Pharmacometrics & Systems Pharmacology . 10, 1, p. 75-83 9 p.

    Research output: Contribution to journalArticlepeer-review

  3. Published

    Choice of oral anticoagulant prescribed by general practices in Wales: Application of Dirichlet regression and linked data

    Hill-McManus, D. & Hughes, D., Jun 2022, In: British Journal of Clinical Pharmacology. 88, 6, p. 2782-2792 11 p.

    Research output: Contribution to journalArticlepeer-review

  4. Published

    Linked Pharmacometric-Pharmacoeconomic Modeling and Simulation in Clinical Drug Development

    Hill-McManus, D., Marshall, S., Liu, J., Willke, R. & Hughes, D., Jul 2021, In: Clinical Pharmacology and Therapeutics. 110, 1, p. 49-63

    Research output: Contribution to journalArticlepeer-review

  5. Published

    Impact of non-adherence and flare resolution on the cost effectiveness of treatments for gout: Application of a linked pharmacometric/pharmacoeconomic model

    Hill-McManus, D., Marshall, S., Soto, E., Lane, S. & Hughes, D., Dec 2018, In: Value in Health. 21, 12, p. 1373-1381

    Research output: Contribution to journalArticlepeer-review

  6. Published

    What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients

    Holmes, E. A., Morrison, V. L. & Hughes, D., Aug 2016, In: British Journal of Clinical Pharmacology. 82, 2, p. 522-531

    Research output: Contribution to journalArticlepeer-review

  7. Published

    A new taxonomy for describing and defining adherence to medications

    Holmes, E. A., Hughes, D., Morrison, V. L., Vrijens, B., De Geest, S., Hughes, D. A., Prezemyslaw, K., Demonceau, J., Ruppar, T., Dobbels, F., Fargher, E., Morrison, V., Lewek, P., Matyjaszczyk, M., Mshelia, C., Clyne, W., Aronson, J. K. & Urquhart, J., 1 May 2012, In: British Journal of Clinical Pharmacology. 73, 5, p. 691-705

    Research output: Contribution to journalArticlepeer-review

  8. Published

    New advice on switching antiepileptic drugs might be a false economy

    Holmes, E. A., Plumpton, C. O., Hughes, D., Holmes, E., Plumpton, C., Duerden, M., Marson, T. & Hughes, D. A., 16 Dec 2013, In: British Medical Journal. 347

    Research output: Contribution to journalArticlepeer-review

  9. Published

    Predicting Adherence to Medications Using Health Psychology Theories: A Systematic Review of 20 Years of Empirical Research

    Holmes, E. A., Morrison, V. L. & Hughes, D., 8 Dec 2014, In: Value in Health. 17, 8, p. 863-876

    Research output: Contribution to journalArticlepeer-review

  10. Published

    Developing an alternative care pathway for emergency ambulance responses for adults with epilepsy: A Discrete Choice Experiment to understand which configuration service users prefer. Part of the COLLABORATE project

    Holmes, E., Dixon, P., Mathieson, A., Ridsdale, L., Morgan, M., McKinlay, A., Dickson, J., Goodacre, S., Jackson, M., Foster, D., Hardman, K., Bell, S., Marson, A., Hughes, D. & Noble, A. J., Apr 2024, In: Seizure: European Journal of Epilepsy. 118, p. 28-37 10 p.

    Research output: Contribution to journalArticlepeer-review

  11. Published

    Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care

    Holmes, E., Harris, S. D., Hughes, A., Craine, N. & Hughes, D., 7 Dec 2018, In: Antibiotics. 7, 4, 19 p., 106.

    Research output: Contribution to journalArticlepeer-review

  12. Published

    A model-based cost-utility analysis of an automated notification system for deteriorating patients on general wards

    Holmes, E., Hughes, D. & Subbe, C., 2 May 2024, In: PLoS ONE. 19, 5, e0301643.

    Research output: Contribution to journalArticlepeer-review

  13. Published

    Patient preferences for outcomes in clinical trials: implications for medicines optimization

    Holmes, E., Marson, A. G. & Hughes, D., 8 May 2017, In: Trials. 18 (Suppl 1), O18, p. 192 1 p.

    Research output: Contribution to journalMeeting Abstractpeer-review

  14. Published

    Challenges for economic evaluation of strategies to contain antimicrobial resistance

    Holmes, E. & Hughes, D., 27 Sept 2019, In: Antibiotics. 8, 4, 8 p., 166.

    Research output: Contribution to journalComment/debatepeer-review

  15. Published

    Patient-focused drug development methods for benefit-risk assessments: A case study using discrete choice experiment for antiepileptic drugs

    Holmes, E. A. F., Plumpton, C., Baker, G. A., Jacoby, A., Ring, A., Williamson, P., Marson, A. & Hughes, D. A., Mar 2019, In: Clinical Pharmacology and Therapeutics. 105, 3, p. 672-683 12 p.

    Research output: Contribution to journalArticlepeer-review

  16. Published

    Mechanism-Based Approach to the Economic Evaluation of Pharmaceuticals: Pharmacokinetic/Pharmacodynamic/Pharmacoeconomic Analysis of Rituximab for Follicular Lymphoma.

    Hughes, D., Pink, J., Lane, S. & Hughes, D. A., 19 Mar 2012, In: Pharmacoeconomics.

    Research output: Contribution to journalArticlepeer-review

  17. Published

    Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations.

    Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Nov 2007, In: Value in Health. 10, 6, p. 498-509

    Research output: Contribution to journalArticlepeer-review

  18. Published

    Effects of the abolition of prescription charges in Wales: A preliminary analysis

    Hughes, D., Hughes, D. A., Alam, F., Cohen, D., Dunstan, F. & Routledge, P., 1 Apr 2008.

    Research output: Contribution to conferencePaper

  19. Published

    Pharmacogenetic tests: the need for a level playing field

    Hughes, D., Pirmohamed, M. & Hughes, D. A., 1 Jan 2013, In: Nature Reviews Drug Discovery. 12, 3-4

    Research output: Contribution to journalArticlepeer-review

  20. Published

    What determines which interventions improve compliance, and do they improve health outcomes in a cost-effective manner?

    Hughes, D., Hughes, D. A., LaFleur.*, N. V., Salas, M. & Shinogle, J., 1 May 2007.

    Research output: Contribution to conferencePaper

  21. Published

    All Wales Medicines Strategy Group Final Appraisal Report - Atazanavir (Reyataz) in treatment-experienced patients.

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

    Research output: Book/ReportCommissioned report

  22. Published

    Adverse drug reactions in economic evaluations

    Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Value in Health. 10, 3, p. A109

    Research output: Contribution to journalArticlepeer-review

  23. Published

    All Wales Medicines Strategy Group Final Appraisal Report - Tenofovir disoproxil fumarate (Viread) for the treatment of hepatitis B.

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2008, 2008 ed. Unknown.

    Research output: Book/ReportCommissioned report

  24. Published

    The influence of non-compliance on the effectiveness and cost-effectiveness of drug therapies.

    Hughes, D. & Hughes, D. A., 1 Jan 2001, 2001 ed. Unknown.

    Research output: Book/ReportCommissioned report

  25. Published

    All Wales Medicines Strategy Group Final Appraisal Report – Clofarabine (Evoltra)

    Hughes, D., Hughes, D. A. & All Wales Strategy Group., N. V., 1 Jan 2007, 2007 ed. Unknown.

    Research output: Book/ReportCommissioned report

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