Research Portal

Professor Dyfrig Hughes

Athro mewn Ffarmacoeconomeg / Cyfarwyddwr Ymchwil

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ORCID: 0000-0001-8247-7459
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  1. Article › Research › Peer-reviewed
  2. Published

    Societal views on NICE, cancer drugs fund and value-based pricing criteria for prioritising medicines: a cross-sectional survey of 4118 adults in Great Britain

    Hughes, D., Linley, W. G. & Hughes, D. A., 1 Aug 2013, In: Health Economics. 22, 8, p. 948-964

    Research output: Contribution to journal › Article › peer-review

  3. Published

    Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Non-adherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers

    Alshreef, A., Latimer, N., Tappenden, P., Wong, R., Hughes, D., Fotheringham, J. & Dixon, S., Nov 2019, In: Medical Decision Making. 39, 8, p. 910-925 16 p.

    Research output: Contribution to journal › Article › peer-review

  4. Published

    Statistical comments are unfounded.

    Hughes, D., Hughes, D. A., Cowell, W., Koncz, T. & Cramer, J., 1 Mar 2008, In: Value in Health. 11, 2, p. 346

    Research output: Contribution to journal › Article › peer-review

  5. Published

    Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of Standard And New Antiepileptic Drugs (SANAD-II)

    Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P., Appleton, R., Leach, J. P., Johnson, M., Baker, G. A., Pirmohamed, M., Hughes, D., Williamson, P., Tudor-Smith, C. & Marson, A. G., 26 Aug 2020, In: BMJ Open. 10, 8, e040635.

    Research output: Contribution to journal › Article › peer-review

  6. Published

    Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections

    Blair, J., Gregory, J., Hughes, D., Ridyard, C., Gamble, C., McKay, A., Didi, M., Thornborough, K., Bedson, E., Awoyale, L., Cwiklinski, E. & Peak, M., 16 Apr 2015, In: Trials. 16, 163.

    Research output: Contribution to journal › Article › peer-review

  7. Published

    Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica

    Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., Foster, N. E., Walsh, D. A., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S. & Wilkinson, C., 31 Oct 2017, In: Health Technology Assessment. 21, 60, p. 1-180 180 p.

    Research output: Contribution to journal › Article › peer-review

  8. Published

    Superiority and cost-effectiveness of monthly extended-release buprenorphine versus daily standard of care medication: a pragmatic, parallel-group, open-label, multicentre, randomised, controlled, phase 3 trial

    Marsden, J., Kelleher, M., Gilvarry, E., Mitcheson, L., Bisla, J., Cape, A., Cowden, F., Day, E., Dewhurst, J., Evans, R., Hardy, W., Hearn, A., Kelly, J., Lowry, N., McCusker, M., Murphy, C., Murray, R., Myton, T., Quarshie, S., Vanderwaal, R., Wareham, A., Hughes, D. & Hoare, Z., Dec 2023, In: eClinicalMedicine. 66, 23 p., 102331.

    Research output: Contribution to journal › Article › peer-review

  9. Published

    Supply-side cost-effectiveness thresholds: questions for evidence-based policy

    Sampson, C., Zamora, B., Watson, S., Cairns, J., Chalkidou, K., Cubi-Molla, P., Devlin, N., García-Lorenzo, B., Hughes, D., Leech, A. & Towse, A., Sept 2022, In: Applied Health Economics and Health Policy. 20, 5, p. 651-667

    Research output: Contribution to journal › Article › peer-review

  10. Published

    Supporting People With Type 2 Diabetes in the Effective Use of Their Medicine Through Mobile Health Technology Integrated With Clinical Care to Reduce Cardiovascular Risk: Protocol for an Effectiveness and Cost-effectiveness Randomized Controlled Trial

    Farmer, A. J., Jones, L., Newhouse, N., Kenning, C., Williams, N., Chi, Y., Bartlett, K., Plumpton, C., McSharry, J., Cholerton, R., Holmes, E., Robinson, S., Allen, J., Gudgin, B., Velardo, C., Rutter, H., Horne, R., Tarassenko, L., Williams, V., Locock, L., Rea, R., Yu, L-M., Hughes, D., Bower, P. & French, D. P., 21 Feb 2022, In: JMIR Research Protocols. 11, 2, e32918.

    Research output: Contribution to journal › Article › peer-review

  11. Published

    Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D Feasibility): a randomised feasibility trial protocol

    Farmer, A. J., Allen, J., Bartlett, K., Bower, P., Chi, Y., French, D. P., Gudgin, B., Holmes, E., Horne, R., Hughes, D., Kenning, C., Locock, L., McSharry, J., Miles, L., Newhouse, N., Rea, R., Riga, J., Tarassenko, L., Velardo, C., Williams, N., Williams, V. & Yu, L-M., 29 Dec 2019, In: BMJ Open. 9, 12, e033504.

    Research output: Contribution to journal › Article › peer-review

  12. E-pub ahead of print

    Supporting people with type 2 diabetes in effective use of their medicine through mobile health technology integrated with clinical care (SuMMiT-D pilot): results of a feasibility randomised trial

    SuMMiT-D Collaborative Group , 25 Jan 2024, (E-pub ahead of print) In: Pilot and Feasibility Studies. 10, 1, 15.

    Research output: Contribution to journal › Article › peer-review

  13. Published

    Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc (NERVES): a phase 3, multicentre, open-label, randomised controlled trial and economic evaluation

    Wilby, M. J., Best, A., Wood, E., Burnside, G., Bedson, E., Short, H., Wheatley, D., Hill-McManus, D., Sharma, M., Clark, S., Baranidharan, G., Price, C., Mannion, R., Hutchinson, P. J., Hughes, D., Marson, A. G. & Williamson, P., 1 May 2021, In: The Lancet Rheumatology. 3, 5, p. e347-e356

    Research output: Contribution to journal › Article › peer-review

  14. Published

    Systematic Review: Outcomes and adverse events from randomised trials in Crohn's disease

    Catt, H., Hughes, D., Kirkham, J. K. & Bodger, K., Apr 2019, In: Alimentary Pharmacology and Therapeutics. 49, 8, p. 978-996 19 p.

    Research output: Contribution to journal › Article › peer-review

  15. Published

    TEOS: A framework for constructing operational definitions of medication adherence based on Timelines – Events – Objectives – Sources

    Dima, A. L., Allemann, S. S., Dunbar-Jacobs, J., Hughes, D., Vrijens, B. & Wilson, I., Jun 2021, In: British Journal of Clinical Pharmacology. 87, 6, p. 2521-2533

    Research output: Contribution to journal › Article › peer-review

  16. Published

    The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol

    Hughes, D., Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D. A., Blundell, M., Griffiths, M. J., Solomon, T. & Malluci, C. L., 3 Jan 2014, In: Trials. 15, 14

    Research output: Contribution to journal › Article › peer-review

  17. Published

    The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)

    Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 7 Apr 2020, In: Healthcare. 8, 2, 88.

    Research output: Contribution to journal › Article › peer-review

  18. Published

    The Population Pharmacokinetics of R and S-Warfarin: Effect of Genetic and Clinical Factors

    Hughes, D., Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., Daly, A. K., Aarons, L., Ogungbenro, K., Kamali, F., Hughes, D. A. & Pirmohamed, M., 1 Jan 2012, In: British Journal of Clinical Pharmacology. 73, 1, p. 66-76

    Research output: Contribution to journal › Article › peer-review

  19. Published

    The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial

    Jenkinson, M. D., Javadpour, M., Haylock, B. J., Young, B., Gillard, H., Vinten, J., Bulbeck, H., Das, K., Farrell, M., Looby, S., Hickey, H., Preusser, M., Mallucci, C. L., Hughes, D., Gamble, C. & Weber, D. C., 14 Nov 2015, In: Trials. 16

    Research output: Contribution to journal › Article › peer-review

  20. Published

    The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

    Marson, A., Burnside, G., Appleton, R., Smith, D., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1363-1374

    Research output: Contribution to journal › Article › peer-review

  21. Published

    The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

    Marson, A., Burnside, G., Appleton, R., Leach, J. P., Sills, G., Tudor-Smith, C., Plumpton, C., Hughes, D., Williamson, P., Baker, G. A., Balabanova, S., Taylor, C., Brown, R., Hindley, D., Howell, S., Maguire, M., Mohanraj, R. & Smith, P. E., 10 Apr 2021, In: The Lancet. 397, 10282, p. 1375-1386

    Research output: Contribution to journal › Article › peer-review

  22. Published

    The development of a QALY measure for epilepsy: NEWQOL-6D

    Hughes, D., Mulhern, B., Rowen, D., Jacoby, A., Marson, T., Snape, D., Hughes, D. A., Latimer, N., Baker, G. A. & Brazier, J. E., 1 May 2012, In: Epilepsy and Behavior. 24, 1, p. 36-43

    Research output: Contribution to journal › Article › peer-review

  23. Published

    The difference between effectiveness and efficacy of antimalarial drugs in Kenya.

    Hughes, D., Amin, A. A., Hughes, D. A., Marsh, V., Abuya, T. O., Kokwaro, G. O., Winstanley, P. A., Ochala, S. A. & Snow, R. W., 1 Sept 2004, In: Tropical Medicine and International Health. 9, 9, p. 967-974

    Research output: Contribution to journal › Article › peer-review

  24. E-pub ahead of print

    The experiences and perspectives of people with gout on urate self-monitoring

    Michael, T. J. F., Wright, D. F. B., Chan, J. S., Coleshill, M. J., Aslani, P., Hughes, D., Day, R. O. & Stocker, S. L., 9 Apr 2024, (E-pub ahead of print) In: Health Expectations. 9 p.

    Research output: Contribution to journal › Article › peer-review

  25. Published

    The impact of non-compliance on the cost-effectiveness of pharmaceuticals: A review of the literature.

    Hughes, D., Hughes, D. A., Bagust, A., Haycox, A. & Walley, T., 1 Oct 2001, In: Health Economics. 10, 7, p. 601-615

    Research output: Contribution to journal › Article › peer-review

  26. Published

    The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial

    Carter, B., Bray, L., Al-Najjar, N., Tort Piella, A., Smith, C. T., Spowart, C., Collingwood, A., Crudgington, H., Currier, J., Hughes, D., Wood, E., Martin, R., Morris, C., Roberts, D., Rouncefield-Swales, A., Sutherland, H., Watson, V., Cook, G., Wiggs, L., Gringas, P. & Pal, D., 6 Feb 2023, In: Trials. 24, 1, 83.

    Research output: Contribution to journal › Article › peer-review

  27. Published

    The influence of non-compliance on the effectiveness and cost-effectiveness of drug therapies

    Hughes, D., Hughes, D. A., Bagust, A., Haycox, A. & Walley, T., 1 Jan 2000, In: Value in Health. 3, 5, p. 373

    Research output: Contribution to journal › Article › peer-review

  28. Published

    The new and non-transparent Cancer Drugs Fund

    Wood, E. & Hughes, D., Jan 2020, In: PharmacoEconomics. 38, 1, p. 1-4

    Research output: Contribution to journal › Article › peer-review

  29. Published

    The problem of orphan drugs

    Hughes, D., Ferner, R. E. & Hughes, D. A., 16 Nov 2010, In: British Medical Journal. 341, p. 335-341

    Research output: Contribution to journal › Article › peer-review

  30. Published

    The role of prevention in reducing the economic impact of ME/CFS in Europe: A report from the socioeconomics working group of the European Network on ME/CFS (EUROMENE).

    Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., de Korwin, J-D., Gitto, L., Hughes, D., Hunter, R. M., Trépel, D. & Wang-Steverding, X., 16 Apr 2021, In: Medicina. 57, 4, 388.

    Research output: Contribution to journal › Article › peer-review

  31. Published

    Trends and influences on use of antidiabetic drugs in England, 1992-2003.

    Walley, T., Hughes, D. & Kendall, H., 1 Nov 2005, In: Pharmacoepidemiology and Drug Safety. 14, 11, p. 769-773

    Research output: Contribution to journal › Article › peer-review

  32. Published

    Understanding medication compliance and persistence from an economics perspective

    Hughes, D., Elliot, R. A., Shinogle, J. A., Peele, P., Bhosle, M. & Hughes, D. A., 1 Jan 2008, In: Value in Health. 11, 4, p. 600-610

    Research output: Contribution to journal › Article › peer-review

  33. Published
  34. Published

    Using Routinely Recorded Data in a UK RCT: A Comparison to Standard Prospective Data Collection Methods

    Powell, G., Bonnett, L., Tudor-Smith, C., Hughes, D., Williamson, P. R. & Marson, A. G., 5 Jul 2021, In: Trials. 22, 1, 429.

    Research output: Contribution to journal › Article › peer-review

  35. Published

    Using Routinely Recorded Data in the UK to Assess Outcomes in a Randomised Controlled Trial: The Trials of Access

    Powell, G., Bonnett, L., Smith, C. T., Hughes, D., Williamson, P. & Marson, A., 23 Aug 2017, In: Trials. 18, 11 p., 389.

    Research output: Contribution to journal › Article › peer-review

  36. Published

    Utilising Benefit-Risk Assessments within Clinical Trials – A Protocol for the BRAINS project

    Totton, N., Julious, S., Hughes, D., Cook, J., Biggs, K., Coates, L., Cook, A., Hewitt, C. & Day, S., 19 Jan 2021, In: Trials. 22, 68.

    Research output: Contribution to journal › Article › peer-review

  37. Published

    Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population

    Hughes, D., Mulhern, B., Rowen, D., Snape, D., Jacoby, A., Marson, T., Hughes, D. A., Baker, G. & Brazier, J., 1 Jul 2014, In: Epilepsy and Behavior. 36, p. 12-17

    Research output: Contribution to journal › Article › peer-review

  38. Published

    Value assessment and quantitative benefit-risk modelling of biosimilar infliximab for Crohn’s disease

    Catt, H., Bodger, K., Hughes, D. & Kirkham, J. J., Dec 2019, In: PharmacoEconomics. 37, 12, p. 1509-1523 15 p.

    Research output: Contribution to journal › Article › peer-review

  39. Published

    Value of improving patient safety: Health-economic considerations for Rapid Response Systems – a Rapid Review of the Literature and Expert Round Table

    Subbe, C., Hughes, D., Lewis, S., Holmes, E., Kalkman, C. J., So, R. K., Tranka, S. & Welch, J., 17 Apr 2023, In: BMJ Open. 13, 4, e065819.

    Research output: Contribution to journal › Article › peer-review

  40. Published

    Value-Based Pricing: Incentive for Innovation or Zero Net Benefit?

    Hughes, D. & Hughes, D. A., 1 Sept 2011, In: Pharmacoeconomics. 29, 9, p. 731-735

    Research output: Contribution to journal › Article › peer-review

  41. Published

    Warfarin pharmacogenetics: Economic considerations.

    Hughes, D., Hughes, D. A. & Pirmohamed, M., 1 Jan 2007, In: Pharmacoeconomics. 25, 11, p. 899-902

    Research output: Contribution to journal › Article › peer-review

  42. E-pub ahead of print

    We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment

    Hughes, D., 27 Sept 2023, (E-pub ahead of print) In: Health Economics, Policy and Law.

    Research output: Contribution to journal › Article › peer-review

  43. Published

    What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients

    Holmes, E. A., Morrison, V. L. & Hughes, D., Aug 2016, In: British Journal of Clinical Pharmacology. 82, 2, p. 522-531

    Research output: Contribution to journal › Article › peer-review

  44. Published

    What really matters? A mixed methods study of treatment preferences and priorities among people with epilepsy in the UK

    Ring, A., Jacoby, A., Baker, G., Holmes, E., Hughes, D., Kierans, C. & Marson, A., Jun 2019, In: Epilepsy and Behavior. 95, p. 181-191

    Research output: Contribution to journal › Article › peer-review

  45. Published

    What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics

    Albassam, A. & Hughes, D., Feb 2021, In: European Journal of Clinical Pharmacology. 77, 2, p. 251-260 10 p.

    Research output: Contribution to journal › Article › peer-review

  46. Published

    When drugs don't work - Economic assessment of enhancing compliance with interventions supported by electronic monitoring devices.

    Hughes, D. & Hughes, D. A., 1 Jan 2007, In: Pharmacoeconomics. 25, 8, p. 621-635

    Research output: Contribution to journal › Article › peer-review

  47. Published

    ‘Seizure First Aid Training’ for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial

    Noble, A. J., Marson, A. G., Tudur-Smith, C., Morgan, M., Hughes, D., Goodacre, S. & Ridsdale, L., 24 Jul 2015, In: BMJ Open. 5, 7

    Research output: Contribution to journal › Article › peer-review

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