Dr Lovesha Sivanantharajah
Research Fellow

Overview
I am a molecular neurobiologist interested in understanding the mechanisms that underlie aging and neurodegeneration. My work uses the power of Drosophila melanogaster genetics coupled with an array of molecular, cellular, behavioural, imaging and bioinformatics approaches to better understand the molecular processes that define normal aging and identify how these processes are altered in pathological aging and neurodegenerative diseases.
Research
Molecular Biology | Animal models | Neurodegeneration |Aging | Alzheimer's Disease
We are interested in understanding selective vulnerability of neurons to pathogenic proteins such as the tangle-forming protein, tau, in Alzheimer's Disease. This involves characterising neuronal vulnerability to tau variants and identifying genes that may mediate vulnerability or resistance to tau.
Research outputs (9)
- Accepted/In press
Examining the vulnerability of adult neuron subtypes to tau-mediated toxicity in Drosophila
Research output: Contribution to journal › Article › peer-review
- Published
Tau-mediated axonal degeneration is prevented by activation of the WldS pathway
Research output: Contribution to journal › Article › peer-review
- Published
Curcumin as a Holistic Treatment for Tau Pathology
Research output: Contribution to journal › Article › peer-review
Prof. activities and awards (3)
Using the fruit fly for research @ Darganfod Discover 2024 (Wrexham's Science Festival)
Activity: Other › Types of Public engagement and outreach - Media article or participation
Southwest Fly Meeting at Bristol University
Activity: Talk or presentation › Oral presentation
Alzheimer's Research UK Research Conference
Activity: Participating in or organising an event › Participation in Academic conference
Accolades (2)
Identifying the mechanisms involved in differential vulnerability of neurons to tau-mediated toxicity
Prize: Fellowship awarded competitively
Alzheimer's Society Senior Fellowship
Prize: Fellowship awarded competitively
Projects (3)
HEFCW HEIR COVID extension to Charities bid (R35C40, F006505)
Project: Research