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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology. / Sandoo, A.; Kitas, G.D.

In: Journal of Visualized Experiments, Vol. 96, 02.07.2015, p. e52339.

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Sandoo, A. ; Kitas, G.D. / A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology. In: Journal of Visualized Experiments. 2015 ; Vol. 96. pp. e52339.

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TY - JOUR

T1 - A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

AU - Sandoo, A.

AU - Kitas, G.D.

PY - 2015/7/2

Y1 - 2015/7/2

N2 - The endothelium is the innermost lining of the vasculature and is involved in the maintenance of vascular homeostasis. Damage to the endothelium may predispose the vessel to atherosclerosis and increase the risk for cardiovascular disease. Assessments of peripheral endothelial function are good indicators of early abnormalities in the vascular wall and correlate well with assessments of coronary endothelial function. The present manuscript details the important methodological steps necessary for the assessment of microvascular endothelial function using laser Doppler imaging with iontophoresis, large vessel endothelial function using flow-mediated dilatation, and carotid atherosclerosis using carotid artery ultrasound. A discussion on the methodological considerations for each of the techniques is also presented, and recommendations are made for future research.

AB - The endothelium is the innermost lining of the vasculature and is involved in the maintenance of vascular homeostasis. Damage to the endothelium may predispose the vessel to atherosclerosis and increase the risk for cardiovascular disease. Assessments of peripheral endothelial function are good indicators of early abnormalities in the vascular wall and correlate well with assessments of coronary endothelial function. The present manuscript details the important methodological steps necessary for the assessment of microvascular endothelial function using laser Doppler imaging with iontophoresis, large vessel endothelial function using flow-mediated dilatation, and carotid atherosclerosis using carotid artery ultrasound. A discussion on the methodological considerations for each of the techniques is also presented, and recommendations are made for future research.

U2 - 10.3791%2F52339

DO - 10.3791%2F52339

M3 - Article

VL - 96

SP - e52339

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

ER -