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  • Rossela Roberts
  • Abigail Neasham
    Cardiff University
  • Chania Lambrinudi
    Cardiff University
  • Ashan Khan
    Betsi Cadwaladr University Health Board NHS Wales
This study aims to assess the current antipsychotic prescribing trends for the treatment of schizophrenia and to compare them with available guidelines and research evidence.

An observational retrospective quantitative analysis.

Data were collected from the prescribing cost analysis for the period between 2007 and 2014, including all drugs from the British National Formulary 4.2.1 and 4.2.2. Prescriptions were included from primary and secondary healthcare settings in England and Wales.

Main outcome measures
Defined daily doses of antipsychotics were used to compare popularity of individual drugs and classes of antipsychotics.

There is a consistent increase in the proportion of atypical antipsychotics prescribed, compared to typical antipsychotics, between 2007 and 2014, with atypicals accounting for 79.9% of total antipsychotics prescribed in 2014.

The consistent popularity of atypical antipsychotics is not concordant with the current National Institute for Health and Care Excellence guidelines for the treatment of schizophrenia or the most recent research evidence.


  • Psychotic disorders, Guidelines, Medicines regulation, Changing physician behaviour
Original languageEnglish
JournalJournal of the Royal Society of Medicine
Issue number4
Early online date1 Apr 2018
Publication statusPublished - 18 Apr 2018

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