Electronic versions

Documents

DOI

  • Paul Little
    University of Southampton
  • Katherine Bradbury
    University of Southampton
  • Beth Stuart
    University of Southampton
  • Jane Barnett
    University of Southampton
  • Adele Krusche
    University of Southampton
  • Mary Steele
    University of Southampton
  • Elena Heber
    University of Southampton
  • Steph Easton
    University of Southampton
  • Kirsten A. Smith
    University of Southampton
  • Joanna Slodowska-Barabasz
    Oxford Brookes University
  • Liz Payne
    University of Southampton
  • Teresa Corbett
    University of Southampton
  • Laura Wilde
    University of Southampton
  • Guiqong LIly Yao
    University of Southampton
  • Sebastien Pollet
    University of Southampton
  • Jazzine Smith
    University of Southampton
  • Judith Joseph
    University of Southampton
  • Megan Lawrence
    University of Southampton
  • Dankmar Böhning
    University of Southampton
  • Tara Cheetham-Blake
    University of Southampton
  • Diana Eccles
    University of Southampton
  • Claire Foster
    University of Southampton
  • Adam William Alfred Geraghty
    University of Southampton
  • Geraldine Leydon
    University of Southampton
  • Andre Matthias Müller
    National University of Singapore
  • Richard D. Neal
    University of Exeter
  • Richard Osborne
    Dorset Cancer Centre, Poole, UK.
  • Shanaya Rathod
    Southern Health NHS Foundation Trust, Southampton, UK.
  • Alison Richardson
    University of Southampton
  • Chloe Grimmett
    University of Southampton
  • Geoffrey Sharman
    Public & Patient Inclusion
  • Roger Bacon
    Public & Patient Inclusion
  • Lesley Turner
    Public & Patient Inclusion
  • RIchard Stephens
    University of Southampton
  • Kirsty Rogers
    University of Southampton
  • James Raftery
    University of Southampton
  • Shihua Zhu
    University of Southampton
  • Karmpaul Singh
    University of Calgary
  • Frances Webley
    University of Southampton
  • Gareth Griffiths
    University of Southampton
  • Jaqui Nutall
    University of Southampton
  • Trudie Chalder
    Kings College London
  • Clare Wilkinson
  • Ella Watson
    Oxford Brookes University
  • Lucy Yardley
    University of Bristol
Background
Many cancer survivors following primary treatment have prolonged poor quality of life.
Aim. To determine the effectiveness of a bespoke digital intervention to support cancer survivors.
Design. Pragmatic parallel open randomised trial.
Setting. UK general practices.
Methods. People having finished primary treatment (<= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score <85, were randomised by online software to: 1)detailed ‘generic’ digital NHS support (‘LiveWell’;n=906), 2) a bespoke complex digital intervention (‘Renewed’;n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) ‘Renewed-with-support’ (n=903): ‘Renewed’ with additional brief email and telephone support.
Results. Mixed linear regression provided estimates of the differences between each intervention group and generic advice: at 6 months (primary time point: n’s respectively 806;749;705) all groups improved, with no significant between-group differences for EORTC QLQ-C30, but global health improved more in both intervention groups. By 12 months there were: small improvements in EORTC QLQ-C30 for Renewed-with-support (versus generic advice: 1.42, 95% CIs 0.33-2.51); both groups improved global health (12 months: renewed: 3.06, 1.39-4.74; renewed-with-support: 2.78, 1.08-4.48), dyspnoea, constipation, and enablement, and lower NHS costs (generic advice £265: in comparison respectively £141 (153-128) and £77 (90-65) lower); and for Renewed-with-support improvement in several other symptom subscales. No harms were identified.
Conclusion. Cancer survivors quality of life improved with detailed generic online support. Robustly developed bespoke digital support provides limited additional short term benefit, but additional longer term improvement in global health enablement and symptom management, with substantially lower NHS costs.
Original languageEnglish
JournalBritish Journal of General Practice
Early online date20 Dec 2023
DOIs
Publication statusE-pub ahead of print - 20 Dec 2023

Total downloads

No data available
View graph of relations