TY - JOUR

T1 - A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025

AU - Pickett, James

AU - Bird, Cathy

AU - Ballard, Clive

AU - Banerjee, Sube

AU - Brayne, Carol

AU - Gowan, Katherine

AU - Clare, Linda

AU - Comas-Herrera, Adelina

AU - Corner, Lynne

AU - Daley, Stephanie

AU - Knapp, Martin

AU - Lafortune, Louise

AU - Livingston, Gill

AU - Manthorpe, Jill

AU - Marchant, Natalie

AU - Moriarty, Jo

AU - Robinson, Louise

AU - van Lynden, Clare

AU - Windle, Gillian

AU - Woods, Robert

AU - Gray, Katherine

AU - Walton, Clare

PY - 2018/7

Y1 - 2018/7

N2 - Objective: National and global dementia plans have focused on the research ambition to develop a cure or disease‐modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas ofprevention, diagnosis, intervention, and care and strategies for achieving them.Methods: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advancedementia research.Results: The taskforce developed 5 goals and 30 recommendations. The goals focused on preventing future cases of dementia through risk reduction, maximising the benefit of a dementia diagnosis, improving quality of life, enabling the dementia workforce to improve practice, andoptimising the quality and inclusivity of health and social care systems. Recommendations addressed gaps in knowledge and limitations in research methodology or infrastructure that would facilitate research in prioritised areas. A 10‐point action plan provides strategies for delivering the proposed research agenda.Conclusions: By creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives.This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families.

AB - Objective: National and global dementia plans have focused on the research ambition to develop a cure or disease‐modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas ofprevention, diagnosis, intervention, and care and strategies for achieving them.Methods: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advancedementia research.Results: The taskforce developed 5 goals and 30 recommendations. The goals focused on preventing future cases of dementia through risk reduction, maximising the benefit of a dementia diagnosis, improving quality of life, enabling the dementia workforce to improve practice, andoptimising the quality and inclusivity of health and social care systems. Recommendations addressed gaps in knowledge and limitations in research methodology or infrastructure that would facilitate research in prioritised areas. A 10‐point action plan provides strategies for delivering the proposed research agenda.Conclusions: By creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives.This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families.

KW - Care

KW - Dementia Research Policy

KW - Research Funding

KW - Risk reduction

KW - Social and applied Science

KW - 2025 Goals for dementia

U2 - 10.1002/gps.4868

DO - 10.1002/gps.4868

M3 - Article

VL - 33

SP - 900

EP - 906

JO - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

IS - 7

ER -