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A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies

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A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies. / Simpson, Lydia; Steinback, Craig ; Stembridge, Mike et al.
In: Experimental Physiology, Vol. 106, No. 2, 01.02.2021, p. 377-384.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Simpson, L, Steinback, C, Stembridge, M & Moore, J 2021, 'A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies', Experimental Physiology, vol. 106, no. 2, pp. 377-384. https://doi.org/10.1113/EP089194

APA

Simpson, L., Steinback, C., Stembridge, M., & Moore, J. (2021). A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies. Experimental Physiology, 106(2), 377-384. https://doi.org/10.1113/EP089194

CBE

Simpson L, Steinback C, Stembridge M, Moore J. 2021. A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies. Experimental Physiology. 106(2):377-384. https://doi.org/10.1113/EP089194

MLA

Simpson, Lydia et al. "A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies". Experimental Physiology. 2021, 106(2). 377-384. https://doi.org/10.1113/EP089194

VancouverVancouver

Simpson L, Steinback C, Stembridge M, Moore J. A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies. Experimental Physiology. 2021 Feb 1;106(2):377-384. Epub 2020 Dec 20. doi: 10.1113/EP089194

Author

Simpson, Lydia ; Steinback, Craig ; Stembridge, Mike et al. / A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies. In: Experimental Physiology. 2021 ; Vol. 106, No. 2. pp. 377-384.

RIS

TY - JOUR

T1 - A sympathetic view of blood pressure control at high altitude: new insights from microneurographic studies

AU - Simpson, Lydia

AU - Steinback, Craig

AU - Stembridge, Mike

AU - Moore, Jonathan

N1 - © 2020 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - NEW FINDINGS: What is the topic of the review? Sympathoexcitation and sympathetic control of blood pressure at high altitude. What advances does it highlight? Sustained sympathoexcitation is fundamental to integrative control of blood pressure in humans exposed to chronic hypoxia. The largest gaps in current knowledge are in understanding the complex mechanisms by which central sympathetic outflow is regulated at high altitude.ABSTRACT: High altitude (HA) hypoxia is a potent activator of the sympathetic nervous system, eliciting increases in sympathetic vasomotor activity. Microneurographic evidence of HA sympathoexcitation dates back to the late 20th century, yet only recently have the characteristics and underpinning mechanisms been explored in detail. This review summarises recent findings and highlights the importance of HA sympathoexcitation for the regulation of blood pressure in lowlanders and indigenous highlanders. In addition, this review identifies gaps in our knowledge and corresponding avenues for future study.

AB - NEW FINDINGS: What is the topic of the review? Sympathoexcitation and sympathetic control of blood pressure at high altitude. What advances does it highlight? Sustained sympathoexcitation is fundamental to integrative control of blood pressure in humans exposed to chronic hypoxia. The largest gaps in current knowledge are in understanding the complex mechanisms by which central sympathetic outflow is regulated at high altitude.ABSTRACT: High altitude (HA) hypoxia is a potent activator of the sympathetic nervous system, eliciting increases in sympathetic vasomotor activity. Microneurographic evidence of HA sympathoexcitation dates back to the late 20th century, yet only recently have the characteristics and underpinning mechanisms been explored in detail. This review summarises recent findings and highlights the importance of HA sympathoexcitation for the regulation of blood pressure in lowlanders and indigenous highlanders. In addition, this review identifies gaps in our knowledge and corresponding avenues for future study.

KW - blood pressure control

KW - high altitude

KW - microneurography

KW - muscle sympathetic nerve activity

U2 - 10.1113/EP089194

DO - 10.1113/EP089194

M3 - Article

C2 - 33345334

VL - 106

SP - 377

EP - 384

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 2

ER -