Advances in MRI biomarkers for the diagnosis of Alzheimer's disease

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  • Elizabeth G Kehoe
    Trinity College Dublin
  • Jonathan P McNulty
    School of Medicine and Medical Science, University College Dublin, Ireland
  • Paul G Mullins
  • Arun L W Bokde
    Trinity College Dublin

With the prevalence of Alzheimer's disease (AD) predicted to increase substantially over the coming decades, the development of effective biomarkers for the early detection of the disease is paramount. In this short review, the main neuroimaging techniques which have shown potential as biomarkers for AD are introduced, with a focus on MRI. Structural MRI measures of the hippocampus and medial temporal lobe are still the most clinically validated biomarkers for AD, but newer techniques such as functional MRI and diffusion tensor imaging offer great scope in tracking changes in the brain, particularly in functional and structural connectivity, which may precede gray matter atrophy. These new advances in neuroimaging methods require further development and crucially, standardization; however, before they are used as biomarkers to aid in the diagnosis of AD.


  • Alzheimer Disease, Biomarkers, Functional Neuroimaging, Hippocampus, Humans, Magnetic Resonance Imaging, Temporal Lobe, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)1151-69
Number of pages19
JournalBiomarkers in Medicine
Issue number9
Publication statusPublished - 1 Oct 2014

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