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Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

Research output: Contribution to journal › Article › peer-review

Standard Standard

Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. / Hughes, D.; Charles, J.M.; Dawoud, D.M. et al.
In: Pharmacoeconomics, Vol. 34, No. 5, 05.2016, p. 447-461.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Hughes, D, Charles, JM, Dawoud, DM, Edwards, RT, Holmes, EA, Jones, CL, Parham, P, Plumpton, C, Ridyard, CO, Lloyd-Williams, H, Wood, EM & Yeo, S 2016, 'Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches', Pharmacoeconomics, vol. 34, no. 5, pp. 447-461. https://doi.org/10.1007/s40273-015-0371-y

APA

Hughes, D., Charles, J. M., Dawoud, D. M., Edwards, R. T., Holmes, E. A., Jones, C. L., Parham, P., Plumpton, C., Ridyard, C. O., Lloyd-Williams, H., Wood, E. M., & Yeo, S. (2016). Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. Pharmacoeconomics, 34(5), 447-461. https://doi.org/10.1007/s40273-015-0371-y

CBE

Hughes D, Charles JM, Dawoud DM, Edwards RT, Holmes EA, Jones CL, Parham P, Plumpton C, Ridyard CO, Lloyd-Williams H, et al. 2016. Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. Pharmacoeconomics. 34(5):447-461. https://doi.org/10.1007/s40273-015-0371-y

MLA

Hughes, D. et al. "Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches". Pharmacoeconomics. 2016, 34(5). 447-461. https://doi.org/10.1007/s40273-015-0371-y

VancouverVancouver

Hughes D, Charles JM, Dawoud DM, Edwards RT, Holmes EA, Jones CL et al. Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. Pharmacoeconomics. 2016 May;34(5):447-461. doi: 10.1007/s40273-015-0371-y

Author

Hughes, D. ; Charles, J.M. ; Dawoud, D.M. et al. / Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches. In: Pharmacoeconomics. 2016 ; Vol. 34, No. 5. pp. 447-461.

RIS

TY - JOUR

T1 - Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

AU - Hughes, D.

AU - Charles, J.M.

AU - Dawoud, D.M.

AU - Edwards, R.T.

AU - Holmes, E.A.

AU - Jones, C.L.

AU - Parham, Paul

AU - Plumpton, Catrin

AU - Ridyard, C.olin

AU - Lloyd-Williams, Huw

AU - Wood, E.M.

AU - Yeo, Seow

PY - 2016/5

Y1 - 2016/5

N2 - Trial-based economic evaluations are an important aspect of health technology assessment. The availability of patient-level data coupled with unbiased estimates of clinical outcomes means that randomised controlled trials are effective vehicles for the generation of economic data. However there are methodological challenges to trial-based evaluations, which include the collection of reliable data on resource use and cost, choice of health outcome measure, calculating minimally important differences, dealing with missing data, extrapolating outcomes and costs over time and the analysis of multinational trials. This review focuses on the state of the art of selective elements concerning the design, conduct, analysis and reporting of trial-based economic evaluations. The limitations of existing approaches are detailed and novel methods introduced. The review is internationally relevant but with a focus towards practice in the UK.

AB - Trial-based economic evaluations are an important aspect of health technology assessment. The availability of patient-level data coupled with unbiased estimates of clinical outcomes means that randomised controlled trials are effective vehicles for the generation of economic data. However there are methodological challenges to trial-based evaluations, which include the collection of reliable data on resource use and cost, choice of health outcome measure, calculating minimally important differences, dealing with missing data, extrapolating outcomes and costs over time and the analysis of multinational trials. This review focuses on the state of the art of selective elements concerning the design, conduct, analysis and reporting of trial-based economic evaluations. The limitations of existing approaches are detailed and novel methods introduced. The review is internationally relevant but with a focus towards practice in the UK.

U2 - 10.1007/s40273-015-0371-y

DO - 10.1007/s40273-015-0371-y

M3 - Article

VL - 34

SP - 447

EP - 461

JO - Pharmacoeconomics

JF - Pharmacoeconomics

SN - 1170-7690

IS - 5

ER -