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Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice

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Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice. / ten Brinke, Michiel M; Boele, Henk-Jan; Spanke, Jochen K et al.
In: Cell Reports, Vol. 13, No. 9, 01.12.2015, p. 1977-88.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

ten Brinke, MM, Boele, H-J, Spanke, JK, Potters, J-W, Kornysheva, K, Wulff, P, IJpelaar, ACHG, Koekkoek, SKE & De Zeeuw, CI 2015, 'Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice', Cell Reports, vol. 13, no. 9, pp. 1977-88. https://doi.org/10.1016/j.celrep.2015.10.057

APA

ten Brinke, M. M., Boele, H.-J., Spanke, J. K., Potters, J.-W., Kornysheva, K., Wulff, P., IJpelaar, A. C. H. G., Koekkoek, S. K. E., & De Zeeuw, C. I. (2015). Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice. Cell Reports, 13(9), 1977-88. https://doi.org/10.1016/j.celrep.2015.10.057

CBE

ten Brinke MM, Boele H-J, Spanke JK, Potters J-W, Kornysheva K, Wulff P, IJpelaar ACHG, Koekkoek SKE, De Zeeuw CI. 2015. Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice. Cell Reports. 13(9):1977-88. https://doi.org/10.1016/j.celrep.2015.10.057

MLA

ten Brinke, Michiel M et al. "Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice". Cell Reports. 2015, 13(9). 1977-88. https://doi.org/10.1016/j.celrep.2015.10.057

VancouverVancouver

ten Brinke MM, Boele HJ, Spanke JK, Potters JW, Kornysheva K, Wulff P et al. Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice. Cell Reports. 2015 Dec 1;13(9):1977-88. doi: 10.1016/j.celrep.2015.10.057

Author

ten Brinke, Michiel M ; Boele, Henk-Jan ; Spanke, Jochen K et al. / Evolving Models of Pavlovian Conditioning : Cerebellar Cortical Dynamics in Awake Behaving Mice. In: Cell Reports. 2015 ; Vol. 13, No. 9. pp. 1977-88.

RIS

TY - JOUR

T1 - Evolving Models of Pavlovian Conditioning

T2 - Cerebellar Cortical Dynamics in Awake Behaving Mice

AU - ten Brinke, Michiel M

AU - Boele, Henk-Jan

AU - Spanke, Jochen K

AU - Potters, Jan-Willem

AU - Kornysheva, Katja

AU - Wulff, Peer

AU - IJpelaar, Anna C H G

AU - Koekkoek, Sebastiaan K E

AU - De Zeeuw, Chris I

N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the expression of conditional blink responses (CRs). However, trial-by-trial quantification of this link in awake behaving animals is lacking, and current hypotheses regarding the underlying plasticity mechanisms have diverged from the classical parallel fiber one to the Purkinje cell synapse LTD hypothesis. Here, we establish that acquired simple spike suppression, acquired conditioned stimulus (CS)-related complex spike responses, and molecular layer interneuron (MLI) activity predict the expression of CRs on a trial-by-trial basis using awake behaving mice. Additionally, we show that two independent transgenic mouse mutants with impaired MLI function exhibit motor learning deficits. Our findings suggest multiple cerebellar cortical plasticity mechanisms underlying simple spike suppression, and they implicate the broader involvement of the olivocerebellar module within the interstimulus interval.

AB - Three decades of electrophysiological research on cerebellar cortical activity underlying Pavlovian conditioning have expanded our understanding of motor learning in the brain. Purkinje cell simple spike suppression is considered to be crucial in the expression of conditional blink responses (CRs). However, trial-by-trial quantification of this link in awake behaving animals is lacking, and current hypotheses regarding the underlying plasticity mechanisms have diverged from the classical parallel fiber one to the Purkinje cell synapse LTD hypothesis. Here, we establish that acquired simple spike suppression, acquired conditioned stimulus (CS)-related complex spike responses, and molecular layer interneuron (MLI) activity predict the expression of CRs on a trial-by-trial basis using awake behaving mice. Additionally, we show that two independent transgenic mouse mutants with impaired MLI function exhibit motor learning deficits. Our findings suggest multiple cerebellar cortical plasticity mechanisms underlying simple spike suppression, and they implicate the broader involvement of the olivocerebellar module within the interstimulus interval.

KW - Animals

KW - Behavior, Animal

KW - Blinking

KW - Cerebellar Cortex

KW - Electrophysiological Phenomena

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Nerve Tissue Proteins

KW - Purkinje Cells

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.celrep.2015.10.057

DO - 10.1016/j.celrep.2015.10.057

M3 - Article

C2 - 26655909

VL - 13

SP - 1977

EP - 1988

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 9

ER -