Exercise intensity and duration effects on in vivo immunity.

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  • B.C. Diment
  • M.B. Fortes
  • J.P. Edwards
  • H.G. Hanstock
  • M.D. Ward
  • H.M. Dunstall
  • P.S. Friedmann
  • N.P. Walsh
Purpose: To examine the effects of intensity and duration of exercise stress on induction of in-vivo immunity in humans using experimental contact hypersensitivity (CHS) with the novel antigen Diphenylcyclopropenone (DPCP). Methods: Sixty-four healthy males completed either 30 minutes running at 60% V[spacing dot above]O2peak (30MI); 30 minutes running at 80% V[spacing dot above]O2peak (30HI); 120 minutes running at 60% V[spacing dot above]O2peak (120MI) or seated rest (CON). Twenty-minutes later subjects received a sensitizing dose of DPCP and four-weeks later the strength of immune reactivity was quantified by measuring the cutaneous responses to a low, dose-series challenge with DPCP on the upper inner-arm. Circulating epinephrine, norepinephrine and cortisol were measured pre, post and 1h post-exercise or CON. Next, to better understand whether the decrease in CHS response on 120MI was due to local inflammatory or T-cell mediated processes, in a cross-over design, eleven healthy males performed 120MI and CON and cutaneous responses to a dose-series of the irritant, croton oil (CO) were assessed on the upper inner-arm. Results: Immune induction by DPCP was impaired by 120MI (skin-fold-thickness -67% vs CON; P
Original languageEnglish
Pages (from-to)1390–1398
JournalMedicine and Science in Sports and Exercise
Issue number7
Publication statusPublished - 3 Nov 2014

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