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Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena.

Research output: Contribution to journal › Article › peer-review

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Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena. / Westebury, Michael V.; Hartmann, Stefanie; Barlow, Axel et al.
In: Molecular Biology and Evolution, Vol. 35, No. 5, 01.05.2018, p. 1225–1237.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Westebury, MV, Hartmann, S, Barlow, A, Wiesel, I, Leo, V, Welch, R, Parker, DM, Sicks, F, Ludwig, A & Hofreiter, M 2018, 'Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena.', Molecular Biology and Evolution, vol. 35, no. 5, pp. 1225–1237. https://doi.org/10.1093/molbev/msy037

APA

Westebury, M. V., Hartmann, S., Barlow, A., Wiesel, I., Leo, V., Welch, R., Parker, D. M., Sicks, F., Ludwig, A., & Hofreiter, M. (2018). Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena. Molecular Biology and Evolution, 35(5), 1225–1237. https://doi.org/10.1093/molbev/msy037

CBE

Westebury MV, Hartmann S, Barlow A, Wiesel I, Leo V, Welch R, Parker DM, Sicks F, Ludwig A, Hofreiter M. 2018. Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena. Molecular Biology and Evolution. 35(5): 1225–1237. https://doi.org/10.1093/molbev/msy037

MLA

Westebury, Michael V. et al. "Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena.". Molecular Biology and Evolution. 2018, 35(5). 1225–1237. https://doi.org/10.1093/molbev/msy037

VancouverVancouver

Westebury MV, Hartmann S, Barlow A, Wiesel I, Leo V, Welch R et al. Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena. Molecular Biology and Evolution. 2018 May 1;35(5): 1225–1237. Epub 2018 Mar 8. doi: https://doi.org/10.1093/molbev/msy037

Author

Westebury, Michael V. ; Hartmann, Stefanie ; Barlow, Axel et al. / Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena. In: Molecular Biology and Evolution. 2018 ; Vol. 35, No. 5. pp. 1225–1237.

RIS

TY - JOUR

T1 - Extended and continuous decline in effective population size results in low genomic diversity but no signs of inbreeding in the world’s rarest hyena species, the brown hyena.

AU - Westebury, Michael V.

AU - Hartmann, Stefanie

AU - Barlow, Axel

AU - Wiesel, Ingrid

AU - Leo, Viyanna

AU - Welch, Rebecca

AU - Parker, Daniel M.

AU - Sicks, Florian

AU - Ludwig, Arne

AU - Hofreiter, Michael

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Hyenas (family Hyaenidae), as the sister group to cats (family Felidae), represent a deeply diverging branch within the cat-like carnivores (Feliformia). With an estimated population size of <10,000 individuals worldwide, the brown hyena (Parahyaena brunnea) represents the rarest of the four extant hyena species and has been listed as Near Threatened by the IUCN. Here, we report a high-coverage genome from a captive bred brown hyena and both mitochondrial and low-coverage nuclear genomes of 14 wild-caught brown hyena individuals from across southern Africa. We find that brown hyena harbor extremely low genetic diversity on both the mitochondrial and nuclear level, most likely resulting from a continuous and ongoing decline in effective population size that started ∼1 Ma and dramatically accelerated towards the end of the Pleistocene. Despite the strikingly low genetic diversity, we find no evidence of inbreeding within the captive bred individual and reveal phylogeographic structure, suggesting the existence of several potential subpopulations within the species.

AB - Hyenas (family Hyaenidae), as the sister group to cats (family Felidae), represent a deeply diverging branch within the cat-like carnivores (Feliformia). With an estimated population size of <10,000 individuals worldwide, the brown hyena (Parahyaena brunnea) represents the rarest of the four extant hyena species and has been listed as Near Threatened by the IUCN. Here, we report a high-coverage genome from a captive bred brown hyena and both mitochondrial and low-coverage nuclear genomes of 14 wild-caught brown hyena individuals from across southern Africa. We find that brown hyena harbor extremely low genetic diversity on both the mitochondrial and nuclear level, most likely resulting from a continuous and ongoing decline in effective population size that started ∼1 Ma and dramatically accelerated towards the end of the Pleistocene. Despite the strikingly low genetic diversity, we find no evidence of inbreeding within the captive bred individual and reveal phylogeographic structure, suggesting the existence of several potential subpopulations within the species.

U2 - https://doi.org/10.1093/molbev/msy037

DO - https://doi.org/10.1093/molbev/msy037

M3 - Article

VL - 35

SP - 1225

EP - 1237

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 5

ER -