This chapter outlines the nature of multi- and mixed methods designs demystifying the array of names used to describe such designs and considering their philosophical underpinnings. Following a brief consideration of the prevalence of multi-method and mixed methods in employee relations research, deductive and inductive approaches are discussed. Examples of published employee relations research are used to illustrate multi-method qualitative and quantitative, concurrent triangulation and concurrent embedded mixed methods, as well as sequential exploratory and sequential explanatory mixed methods designs. These, along with a detailed vignette highlight their potential for enabling new insights, revealing how such mixed methods designs have been operationalisation. The potential benefits, challenges and pitfalls of using mixed methods, including the need for methodological fit, are then considered. The chapter concludes with a summary of different ways of combining methods, discussion emphasising key issues, alongside implications for employee relations researchers.