Fish polyomaviruses belong to two distinct evolutionary lineages
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In: Journal of General Virology, Vol. 99, No. 4, 08.03.2018, p. 567-573.
Research output: Contribution to journal › Article › peer-review
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T1 - Fish polyomaviruses belong to two distinct evolutionary lineages
AU - Van Doorslaer, Koenraad
AU - Kraberger, Simona
AU - Austin, Charlotte
AU - Farkas, Kata
AU - Bergeman, Melissa
AU - Paunil, Emma
AU - Davison, William
AU - Varsani, Arvind
PY - 2018/3/8
Y1 - 2018/3/8
N2 - The Polyomaviridae is a diverse family of circular double-stranded DNA viruses. Polyomaviruses have been isolated from a wide array of animal hosts. An understanding of the evolutionary and ecological dynamics of these viruses is essential to understanding the pathogenicity of polyomaviruses. Using a high throughput sequencing approach, we identified a novel polyomavirus in an emerald notothen (Trematomus bernacchii) sampled in the Ross sea (Antarctica), expanding the known number of fish-associated polyomaviruses. Our analysis suggests that polyomaviruses belong to three main evolutionary clades; the first clade is made up of all recognized terrestrial polyomaviruses. The fish-associated polyomaviruses are not monophyletic, and belong to two divergent evolutionary lineages. The fish viruses provide evidence that the evolution of the key viral large T protein involves gain and loss of distinct domains.
AB - The Polyomaviridae is a diverse family of circular double-stranded DNA viruses. Polyomaviruses have been isolated from a wide array of animal hosts. An understanding of the evolutionary and ecological dynamics of these viruses is essential to understanding the pathogenicity of polyomaviruses. Using a high throughput sequencing approach, we identified a novel polyomavirus in an emerald notothen (Trematomus bernacchii) sampled in the Ross sea (Antarctica), expanding the known number of fish-associated polyomaviruses. Our analysis suggests that polyomaviruses belong to three main evolutionary clades; the first clade is made up of all recognized terrestrial polyomaviruses. The fish-associated polyomaviruses are not monophyletic, and belong to two divergent evolutionary lineages. The fish viruses provide evidence that the evolution of the key viral large T protein involves gain and loss of distinct domains.
U2 - 10.1099/jgv.0.001041
DO - 10.1099/jgv.0.001041
M3 - Article
VL - 99
SP - 567
EP - 573
JO - Journal of General Virology
JF - Journal of General Virology
SN - 1465-2099
IS - 4
ER -