TY - JOUR

T1 - Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake

AU - Malinsky, M.

AU - Challis, R.J.

AU - Tyers, A.M.

AU - Schiffels, S.

AU - Terai, Y.

AU - Ngatunga, B.P.

AU - Miska, E.A.

AU - Durbin, R.

AU - Genner, M.J.

AU - Turner, G.F.

N1 - This is the author accepted manuscript. The final version is available from AAAS via http://dx.doi.org/10.1126/science.aac9927 Royal Society–Leverhulme Trust Africa Awards AA100023 and AA130107; Wellcome Trust; Cancer Research UK

PY - 2015/12/18

Y1 - 2015/12/18

N2 - The genomic causes and effects of divergent ecological selection during speciation are still poorly understood. Here, we report the discovery and detailed characterization of earlystage adaptive divergence of two cichlid fish ecomorphs in a small (700m diameter) isolated crater lake in Tanzania. The ecomorphs differ in depth preference, male breeding color, body shape, diet and trophic morphology. With whole genome sequences of 146 fish, we identify 98 clearly demarcated genomic ‘islands’ of high differentiation and demonstrate association of genotypes across these islands to divergent mate preferences. The islands contain candidate adaptive genes enriched for functions in sensory perception (including rhodopsin and other twilight vision associated genes), hormone signaling and morphogenesis. Our study suggests mechanisms and genomic regions that may play a role in the closely related mega-radiation of Lake Malawi.

AB - The genomic causes and effects of divergent ecological selection during speciation are still poorly understood. Here, we report the discovery and detailed characterization of earlystage adaptive divergence of two cichlid fish ecomorphs in a small (700m diameter) isolated crater lake in Tanzania. The ecomorphs differ in depth preference, male breeding color, body shape, diet and trophic morphology. With whole genome sequences of 146 fish, we identify 98 clearly demarcated genomic ‘islands’ of high differentiation and demonstrate association of genotypes across these islands to divergent mate preferences. The islands contain candidate adaptive genes enriched for functions in sensory perception (including rhodopsin and other twilight vision associated genes), hormone signaling and morphogenesis. Our study suggests mechanisms and genomic regions that may play a role in the closely related mega-radiation of Lake Malawi.

U2 - 10.1126/science.aac9927

DO - 10.1126/science.aac9927

M3 - Article

VL - 350

SP - 1493

EP - 1498

JO - Science

JF - Science

SN - 0036-8075

IS - 6267

ER -