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Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia. / Carr, Jay; Stone, Rachel; Tymko, Courtney et al.
In: High Altitude Medicine and Biology, Vol. 21, No. 3, 09.2020, p. 297-302.

Research output: Contribution to journalArticlepeer-review

HarvardHarvard

Carr, J, Stone, R, Tymko, C, Tymko, K, Coombs, GB, Hoiland, RL, Howe, CA, Tymko, MM, Ainslie, PN & Patrician, A 2020, 'Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia', High Altitude Medicine and Biology, vol. 21, no. 3, pp. 297-302. https://doi.org/10.1089/ham.2019.0124

APA

Carr, J., Stone, R., Tymko, C., Tymko, K., Coombs, G. B., Hoiland, R. L., Howe, C. A., Tymko, M. M., Ainslie, P. N., & Patrician, A. (2020). Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia. High Altitude Medicine and Biology, 21(3), 297-302. https://doi.org/10.1089/ham.2019.0124

CBE

Carr J, Stone R, Tymko C, Tymko K, Coombs GB, Hoiland RL, Howe CA, Tymko MM, Ainslie PN, Patrician A. 2020. Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia. High Altitude Medicine and Biology. 21(3):297-302. https://doi.org/10.1089/ham.2019.0124

MLA

VancouverVancouver

Carr J, Stone R, Tymko C, Tymko K, Coombs GB, Hoiland RL et al. Global REACH 2018: The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia. High Altitude Medicine and Biology. 2020 Sept;21(3):297-302. doi: 10.1089/ham.2019.0124

Author

Carr, Jay ; Stone, Rachel ; Tymko, Courtney et al. / Global REACH 2018 : The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia. In: High Altitude Medicine and Biology. 2020 ; Vol. 21, No. 3. pp. 297-302.

RIS

TY - JOUR

T1 - Global REACH 2018

T2 - The Effect of an Expiratory Resistance Mask with Dead Space on Sleep and Acute Mountain Sickness During Acute Exposure to Hypobaric Hypoxia

AU - Carr, Jay

AU - Stone, Rachel

AU - Tymko, Courtney

AU - Tymko, Kaitlyn

AU - Coombs, Geoff B

AU - Hoiland, Ryan L

AU - Howe, Connor A

AU - Tymko, Michael M

AU - Ainslie, Philip N

AU - Patrician, Alexander

PY - 2020/9

Y1 - 2020/9

N2 - Carr, Jay, Rachel Stone, Courtney Tymko, Kaitlyn Tymko, Geoff B. Coombs, Ryan L. Hoiland, Connor A. Howe, Michael M. Tymko, Philip N. Ainslie, and Alexander Patrician. Global REACH 2018: the effect of an expiratory resistance mask with dead space on sleep and acute mountain sickness during acute exposure to hypobaric hypoxia. High Alt Med Biol. 21:297-302, 2020. We hypothesized that an expiratory resistance and dead space (ER/DS) mask, a version of which was previously shown to partially alleviate sleep-disordered breathing and headache severity during acute normobaric hypoxia (Patrician et al.), would exhibit similar results in conditions of hypobaric hypoxia. In a randomized, single-blinded, sham-controlled, and sex-matched design, 31 healthy lowlanders rapidly (6-8 hours) ascended from sea level to 4300 m (Cerro de Pasco, Peru) and slept with either an ER/DS mask (n = 15) or sham mask (n = 16). Sleep was assessed (via WatchPAT) and questionnaires collected before sleep and upon waking the morning after. There was no difference in apnea-hypopnea index (AHI) between the ER/DS (77 ± 20 events/h) or sham mask (84 ± 27 events/h; p = 0.57). In addition, there was no alleviation of headache scores, improvement in sleep quality, or acute mountain sickness symptom severity. Both the sham and ER/DS masks were poorly tolerated (∼50% subject noncompliance in both groups). These findings highlight the importance and necessity of field-testing and demonstrate that more testing is needed before ER/DS devices, such as these, can be recommended for prophylactic benefits at high altitude.

AB - Carr, Jay, Rachel Stone, Courtney Tymko, Kaitlyn Tymko, Geoff B. Coombs, Ryan L. Hoiland, Connor A. Howe, Michael M. Tymko, Philip N. Ainslie, and Alexander Patrician. Global REACH 2018: the effect of an expiratory resistance mask with dead space on sleep and acute mountain sickness during acute exposure to hypobaric hypoxia. High Alt Med Biol. 21:297-302, 2020. We hypothesized that an expiratory resistance and dead space (ER/DS) mask, a version of which was previously shown to partially alleviate sleep-disordered breathing and headache severity during acute normobaric hypoxia (Patrician et al.), would exhibit similar results in conditions of hypobaric hypoxia. In a randomized, single-blinded, sham-controlled, and sex-matched design, 31 healthy lowlanders rapidly (6-8 hours) ascended from sea level to 4300 m (Cerro de Pasco, Peru) and slept with either an ER/DS mask (n = 15) or sham mask (n = 16). Sleep was assessed (via WatchPAT) and questionnaires collected before sleep and upon waking the morning after. There was no difference in apnea-hypopnea index (AHI) between the ER/DS (77 ± 20 events/h) or sham mask (84 ± 27 events/h; p = 0.57). In addition, there was no alleviation of headache scores, improvement in sleep quality, or acute mountain sickness symptom severity. Both the sham and ER/DS masks were poorly tolerated (∼50% subject noncompliance in both groups). These findings highlight the importance and necessity of field-testing and demonstrate that more testing is needed before ER/DS devices, such as these, can be recommended for prophylactic benefits at high altitude.

KW - Altitude

KW - Altitude Sickness

KW - Humans

KW - Hypoxia

KW - Peru

KW - Sleep

U2 - 10.1089/ham.2019.0124

DO - 10.1089/ham.2019.0124

M3 - Article

C2 - 32364805

VL - 21

SP - 297

EP - 302

JO - High Altitude Medicine and Biology

JF - High Altitude Medicine and Biology

SN - 1527-0297

IS - 3

ER -