Graded and sharp transitions in semantic function in left temporal lobe

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  • Katya Krieger-Redwood
    University of York
  • Xiuyi Wang
    Chinese Academy of Sciences, Beijing
  • Nicholas Souter
    University of York
  • Tirso Gonzalez Alam
    University of York
  • Jonathan Smallwood
    Queen’s University, Kingston, Canada
  • Rebecca L. Jackson
    University of York
  • Elizabeth Jefferies
    University of York
Recent work has focussed on how patterns of functional change within the temporal lobe relate to whole-brain dimensions of intrinsic connectivity variation (Margulies et al., 2016). We examined two such ‘connectivity gradients’ reflecting the separation of (i) unimodal versus heteromodal and (ii) visual versus auditory-motor cortex, examining visually presented verbal associative and feature judgments, plus picture-based context and emotion generation. Functional responses along the first dimension sometimes showed graded change between modality-tuned and heteromodal cortex (in the verbal matching task), and other times showed sharp functional transitions, with deactivation at the extremes and activation in the middle of this gradient (internal generation). The second gradient revealed more visual than auditory-motor activation, regardless of content (associative, feature, context, emotion) or task process (matching/generation). We also uncovered subtle differences across each gradient for content type, which predominantly manifested as differences in relative magnitude of activation or deactivation.
Original languageEnglish
Article number105402
JournalBrain and Language
Early online date13 Mar 2024
Publication statusPublished - 1 Apr 2024
Externally publishedYes
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