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High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor

Research output: Contribution to journal › Article › peer-review

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High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. / Hanstock, Helen; Edwards, Jason; Roberts, Ross et al.
In: Biological Psychology, Vol. 133, No. March, 03.2018, p. 85-88.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Hanstock, H, Edwards, J, Roberts, R & Walsh, N 2018, 'High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor', Biological Psychology, vol. 133, no. March, pp. 85-88. https://doi.org/10.1016/j.biopsycho.2018.02.002

APA

Hanstock, H., Edwards, J., Roberts, R., & Walsh, N. (2018). High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. Biological Psychology, 133(March), 85-88. https://doi.org/10.1016/j.biopsycho.2018.02.002

CBE

Hanstock H, Edwards J, Roberts R, Walsh N. 2018. High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. Biological Psychology. 133(March):85-88. https://doi.org/10.1016/j.biopsycho.2018.02.002

MLA

Hanstock, Helen et al. "High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor". Biological Psychology. 2018, 133(March). 85-88. https://doi.org/10.1016/j.biopsycho.2018.02.002

VancouverVancouver

Hanstock H, Edwards J, Roberts R, Walsh N. High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. Biological Psychology. 2018 Mar;133(March):85-88. Epub 2018 Feb 7. doi: 10.1016/j.biopsycho.2018.02.002

Author

Hanstock, Helen ; Edwards, Jason ; Roberts, Ross et al. / High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor. In: Biological Psychology. 2018 ; Vol. 133, No. March. pp. 85-88.

RIS

TY - JOUR

T1 - High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor

AU - Hanstock, Helen

AU - Edwards, Jason

AU - Roberts, Ross

AU - Walsh, Neil

N1 - 12 month embargo

PY - 2018/3

Y1 - 2018/3

N2 - Tear secretory immunoglobulin-A (SIgA) is a putative biomarker of common-cold risk with potential utility in non-invasive diagnostics. As SIgA secretion at the ocular surface is under strong autonomic control, we investigated the relationship between HR reactivity and tear SIgA responses to novel experiential stress. Thirty-two healthy participants undertook a 60 s zip-line ride to evoke acute stress and a seated-rest control trial in a randomised-crossover design. We recorded heart rate (HR) continuously and collected unstimulated tear samples 5 min pre-, 2 min post- and 20 min post-stress/control. Stress increased HR and state anxiety whereas tear SIgA concentration decreased 44% post-stress vs. control. Higher peak HR values during stress uniquely explained 21% of the variance in tear SIgA reactivity to stress (p < 0.01); high HR reactors displayed greater decreases in tear SIgA concentration. We conclude that physiological arousal increases immune reactivity to acute stress and highlight tear SIgA as a minimally-invasive, physiologically relevant biomarker of immune reactivity.

AB - Tear secretory immunoglobulin-A (SIgA) is a putative biomarker of common-cold risk with potential utility in non-invasive diagnostics. As SIgA secretion at the ocular surface is under strong autonomic control, we investigated the relationship between HR reactivity and tear SIgA responses to novel experiential stress. Thirty-two healthy participants undertook a 60 s zip-line ride to evoke acute stress and a seated-rest control trial in a randomised-crossover design. We recorded heart rate (HR) continuously and collected unstimulated tear samples 5 min pre-, 2 min post- and 20 min post-stress/control. Stress increased HR and state anxiety whereas tear SIgA concentration decreased 44% post-stress vs. control. Higher peak HR values during stress uniquely explained 21% of the variance in tear SIgA reactivity to stress (p < 0.01); high HR reactors displayed greater decreases in tear SIgA concentration. We conclude that physiological arousal increases immune reactivity to acute stress and highlight tear SIgA as a minimally-invasive, physiologically relevant biomarker of immune reactivity.

U2 - 10.1016/j.biopsycho.2018.02.002

DO - 10.1016/j.biopsycho.2018.02.002

M3 - Article

VL - 133

SP - 85

EP - 88

JO - Biological Psychology

JF - Biological Psychology

SN - 0301-0511

IS - March

ER -