TY - JOUR

T1 - Inhibitory stimulation of the ventral premotor cortex temporarily interferes with musical beat rate preference

AU - Kornysheva, Katja

AU - von Anshelm-Schiffer, Anne-Marike

AU - Schubotz, Ricarda I

N1 - Copyright © 2010 Wiley-Liss, Inc.

PY - 2011/8

Y1 - 2011/8

N2 - Behavioral studies suggest that preference for a beat rate (tempo) in auditory sequences is tightly linked to the motor system. However, from a neuroscientific perspective the contribution of motor-related brain regions to tempo preference in the auditory domain remains unclear. A recent fMRI study (Kornysheva et al. [2010]: Hum Brain Mapp 31:48-64) revealed that the activity increase in the left ventral premotor cortex (PMv) is associated with the preference for a tempo of a musical rhythm. The activity increase correlated with how strongly the subjects preferred a tempo. Despite this evidence, it remains uncertain whether an interference with activity in the left PMv affects tempo preference strength. Consequently, we conducted an offline repetitive transcranial magnetic stimulation (rTMS) study, in which the cortical excitability in the left PMv was temporarily reduced. As hypothesized, 0.9 Hz rTMS over the left PMv temporarily affected individual tempo preference strength depending on the individual strength of tempo preference in the control session. Moreover, PMv stimulation temporarily interfered with the stability of individual tempo preference strength within and across sessions. These effects were specific to the preference for tempo in contrast to the preference for timbre, bound to the first half of the experiment following PMv stimulation and could not be explained by an impairment of tempo recognition. Our results corroborate preceding fMRI findings and suggest that activity in the left PMv is part of a network that affects the strength of beat rate preference.

AB - Behavioral studies suggest that preference for a beat rate (tempo) in auditory sequences is tightly linked to the motor system. However, from a neuroscientific perspective the contribution of motor-related brain regions to tempo preference in the auditory domain remains unclear. A recent fMRI study (Kornysheva et al. [2010]: Hum Brain Mapp 31:48-64) revealed that the activity increase in the left ventral premotor cortex (PMv) is associated with the preference for a tempo of a musical rhythm. The activity increase correlated with how strongly the subjects preferred a tempo. Despite this evidence, it remains uncertain whether an interference with activity in the left PMv affects tempo preference strength. Consequently, we conducted an offline repetitive transcranial magnetic stimulation (rTMS) study, in which the cortical excitability in the left PMv was temporarily reduced. As hypothesized, 0.9 Hz rTMS over the left PMv temporarily affected individual tempo preference strength depending on the individual strength of tempo preference in the control session. Moreover, PMv stimulation temporarily interfered with the stability of individual tempo preference strength within and across sessions. These effects were specific to the preference for tempo in contrast to the preference for timbre, bound to the first half of the experiment following PMv stimulation and could not be explained by an impairment of tempo recognition. Our results corroborate preceding fMRI findings and suggest that activity in the left PMv is part of a network that affects the strength of beat rate preference.

KW - Acoustic Stimulation

KW - Adult

KW - Auditory Perception

KW - Brain Mapping

KW - Evoked Potentials, Motor

KW - Female

KW - Frontal Lobe

KW - Functional Laterality

KW - Humans

KW - Motor Cortex

KW - Music

KW - Nerve Net

KW - Neural Inhibition

KW - Transcranial Magnetic Stimulation

KW - Journal Article

U2 - 10.1002/hbm.21109

DO - 10.1002/hbm.21109

M3 - Article

C2 - 20715082

VL - 32

SP - 1300

EP - 1310

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1097-0193

IS - 8

ER -