Integrative crosstalk between hypoxia and the cold: old data and new opportunities

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  • Hendrik Mugele
    University of Innsbruck
  • Sam Oliver
  • Daniel Gagnon
    University of Montreal
  • Justin Lawley
    University of Innsbruck
Cold stress and hypoxia have been the subject of research for decades; however, humans often encounter these stressors together, such as in the alpine environment. Therefore, this review summarizes previous data with respect to the influence of hypoxia on thermoregulatory and cardiovascular control in the cold and presents new ideas for the future. Altogether, little to no evidence is available on the integrative and adaptive mechanisms about how the human body regulates heat conservation, oxygen delivery, and maintenance of blood pressure.

Keywords

  • cardiovascular physiology, cold and hypoxia, cutaneous vasoconstriction, thermogenesis
Original languageEnglish
Pages (from-to)350-358
JournalExperimental Physiology
Volume106
Issue number1
Early online date30 Jun 2020
DOIs
Publication statusPublished - 1 Jan 2021

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