Research Portal

Localized 1H NMR spectroscopy of rat spinal cord in vivo

Research output: Contribution to journal › Article › peer-review

Standard Standard

Localized 1H NMR spectroscopy of rat spinal cord in vivo. / Zelaya, F O; Chalk, J B; Mullins, P et al.
In: Magnetic Resonance in Medicine, Vol. 35, No. 4, 04.1996, p. 443-8.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Zelaya, FO, Chalk, JB, Mullins, P, Brereton, IM & Doddrell, DM 1996, 'Localized 1H NMR spectroscopy of rat spinal cord in vivo', Magnetic Resonance in Medicine, vol. 35, no. 4, pp. 443-8. https://doi.org/10.1002/mrm.1910350401

APA

Zelaya, F. O., Chalk, J. B., Mullins, P., Brereton, I. M., & Doddrell, D. M. (1996). Localized 1H NMR spectroscopy of rat spinal cord in vivo. Magnetic Resonance in Medicine, 35(4), 443-8. https://doi.org/10.1002/mrm.1910350401

CBE

Zelaya FO, Chalk JB, Mullins P, Brereton IM, Doddrell DM. 1996. Localized 1H NMR spectroscopy of rat spinal cord in vivo. Magnetic Resonance in Medicine. 35(4):443-8. https://doi.org/10.1002/mrm.1910350401

MLA

Zelaya, F O et al. "Localized 1H NMR spectroscopy of rat spinal cord in vivo". Magnetic Resonance in Medicine. 1996, 35(4). 443-8. https://doi.org/10.1002/mrm.1910350401

VancouverVancouver

Zelaya FO, Chalk JB, Mullins P, Brereton IM, Doddrell DM. Localized 1H NMR spectroscopy of rat spinal cord in vivo. Magnetic Resonance in Medicine. 1996 Apr;35(4):443-8. doi: 10.1002/mrm.1910350401

Author

Zelaya, F O ; Chalk, J B ; Mullins, P et al. / Localized 1H NMR spectroscopy of rat spinal cord in vivo. In: Magnetic Resonance in Medicine. 1996 ; Vol. 35, No. 4. pp. 443-8.

RIS

TY - JOUR

T1 - Localized 1H NMR spectroscopy of rat spinal cord in vivo

AU - Zelaya, F O

AU - Chalk, J B

AU - Mullins, P

AU - Brereton, I M

AU - Doddrell, D M

PY - 1996/4

Y1 - 1996/4

N2 - A movable, actively decoupled surface coil has been employed to obtain a localized 1H NMR spectrum from the lumbosacral spinal cord of a live Lewis rat. A volume selective 'VOSY' normally spelled out as 'volume selective spectroscopy' spectroscopy pulse sequence that incorporates 'phase ramped' selective RF pulses, has been used to minimize random phase jitter in the NMR signal as a result of the large frequency shifts required to locate the voxel in the center of the cord while using intense gradient pulses. Spectra from 13-microliters voxels in healthy rats and in rats inoculated with guinea pig spinal cord and complete Freund's adjuvant, resulting in experimental autoimmune encephalomyelitis, are shown.

AB - A movable, actively decoupled surface coil has been employed to obtain a localized 1H NMR spectrum from the lumbosacral spinal cord of a live Lewis rat. A volume selective 'VOSY' normally spelled out as 'volume selective spectroscopy' spectroscopy pulse sequence that incorporates 'phase ramped' selective RF pulses, has been used to minimize random phase jitter in the NMR signal as a result of the large frequency shifts required to locate the voxel in the center of the cord while using intense gradient pulses. Spectra from 13-microliters voxels in healthy rats and in rats inoculated with guinea pig spinal cord and complete Freund's adjuvant, resulting in experimental autoimmune encephalomyelitis, are shown.

KW - Animals

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Guinea Pigs

KW - Magnetic Resonance Spectroscopy

KW - Male

KW - Rats

KW - Rats, Inbred Lew

KW - Spinal Cord

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/mrm.1910350401

DO - 10.1002/mrm.1910350401

M3 - Article

C2 - 8992192

VL - 35

SP - 443

EP - 448

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -