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MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

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MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. / Bettcher, Brianne M; Fitch, Ryan; Wynn, Matthew J et al.
In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 3, 22.06.2016, p. 91-7.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Bettcher, BM, Fitch, R, Wynn, MJ, Lalli, MA, Elofson, J, Jastrzab, L, Mitic, L, Miller, ZA, Rabinovici, GD, Miller, BL, Kao, AW, Kosik, KS & Kramer, JH 2016, 'MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 3, pp. 91-7. https://doi.org/10.1016/j.dadm.2016.05.004

APA

Bettcher, B. M., Fitch, R., Wynn, M. J., Lalli, M. A., Elofson, J., Jastrzab, L., Mitic, L., Miller, Z. A., Rabinovici, G. D., Miller, B. L., Kao, A. W., Kosik, K. S., & Kramer, J. H. (2016). MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3, 91-7. https://doi.org/10.1016/j.dadm.2016.05.004

CBE

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, et al. 2016. MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 3:91-7. https://doi.org/10.1016/j.dadm.2016.05.004

MLA

Bettcher, Brianne M et al. "MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes". Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2016, 3. 91-7. https://doi.org/10.1016/j.dadm.2016.05.004

VancouverVancouver

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L et al. MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2016 Jun 22;3:91-7. doi: 10.1016/j.dadm.2016.05.004

Author

Bettcher, Brianne M ; Fitch, Ryan ; Wynn, Matthew J et al. / MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2016 ; Vol. 3. pp. 91-7.

RIS

TY - JOUR

T1 - MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

AU - Bettcher, Brianne M

AU - Fitch, Ryan

AU - Wynn, Matthew J

AU - Lalli, Matthew A

AU - Elofson, Jonathan

AU - Jastrzab, Laura

AU - Mitic, Laura

AU - Miller, Zachary A

AU - Rabinovici, Gil D

AU - Miller, Bruce L

AU - Kao, Aimee W

AU - Kosik, Kenneth S

AU - Kramer, Joel H

PY - 2016/6/22

Y1 - 2016/6/22

N2 - INTRODUCTION: MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.METHODS: MCP-1 and eotaxin-1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained.RESULTS: An interaction was noted between MCP-1 and eotaxin-1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non-chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains.DISCUSSION: These results suggest a potentially selective role for MCP-1 and eotaxin-1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

AB - INTRODUCTION: MCP-1 and eotaxin-1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.METHODS: MCP-1 and eotaxin-1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained.RESULTS: An interaction was noted between MCP-1 and eotaxin-1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non-chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains.DISCUSSION: These results suggest a potentially selective role for MCP-1 and eotaxin-1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

U2 - 10.1016/j.dadm.2016.05.004

DO - 10.1016/j.dadm.2016.05.004

M3 - Article

C2 - 27453930

VL - 3

SP - 91

EP - 97

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -