TY - JOUR

T1 - Nanodelivery systems and stabilized solid-drug nanoparticles for orally administered medicine

T2 - current landscape

AU - Kermanizadeh, Ali

AU - Powell, Leagh G

AU - Stone, Vicki

AU - Møller, Peter

PY - 2018/11/16

Y1 - 2018/11/16

N2 - The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications.

AB - The use of nanoparticles as a means of targeted delivery of therapeutics and imaging agents could greatly enhance the transport of biologically active contents to specific target tissues, while avoiding or reducing potentially undesired side effects. Generally speaking, the oral route of administration is associated with good patient compliance, as it is convenient, economical, noninvasive, and does not require special training. Here, we review the progress of the utilization of nanodelivery-system carriers or stabilized solid-drug nanoparticles following oral administration, with particular attention on toxicological data. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge to human scenarios highlighted. Additionally, issues associated with administration of drugs via the oral route are underlined, while strategies utilized to overcome these are highlighted. This review aims to offer a balanced overview of strategies currently being used in the application of nanosize constructs for oral medical applications.

KW - Administration, Oral

KW - Disease

KW - Drug Delivery Systems

KW - Humans

KW - Nanoparticles/chemistry

KW - Pharmaceutical Preparations/administration & dosage

U2 - 10.2147/IJN.S177418

DO - 10.2147/IJN.S177418

M3 - Review article

C2 - 30510419

VL - 13

SP - 7575

EP - 7605

JO - Nanomedicine

JF - Nanomedicine

ER -