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Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial

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Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. / NEuRoMS Collective; Topcu, Gogem; Smith, Laura et al.
In: Pilot and Feasibility Studies, Vol. 8, No. 1, 11.06.2022, p. 123.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

NEuRoMS Collective, Topcu, G, Smith, L, Mhizha-Murira, JR, Goulden, N, Hoare, Z, Drummond, A, Fitzsimmons, D, Evangelou, N, Schmierer, K, Tallantyre, EC, Leighton, P, Allen-Philbey, K, Stennett, A, Bradley, P, Bale, C, Turton, J & das Nair, R 2022, 'Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial', Pilot and Feasibility Studies, vol. 8, no. 1, pp. 123. https://doi.org/10.1186/s40814-022-01073-5

APA

NEuRoMS Collective, Topcu, G., Smith, L., Mhizha-Murira, J. R., Goulden, N., Hoare, Z., Drummond, A., Fitzsimmons, D., Evangelou, N., Schmierer, K., Tallantyre, E. C., Leighton, P., Allen-Philbey, K., Stennett, A., Bradley, P., Bale, C., Turton, J., & das Nair, R. (2022). Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies, 8(1), 123. https://doi.org/10.1186/s40814-022-01073-5

CBE

NEuRoMS Collective, Topcu G, Smith L, Mhizha-Murira JR, Goulden N, Hoare Z, Drummond A, Fitzsimmons D, Evangelou N, Schmierer K, et al. 2022. Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies. 8(1):123. https://doi.org/10.1186/s40814-022-01073-5

MLA

NEuRoMS Collective et al. "Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial". Pilot and Feasibility Studies. 2022, 8(1). 123. https://doi.org/10.1186/s40814-022-01073-5

VancouverVancouver

NEuRoMS Collective, Topcu G, Smith L, Mhizha-Murira JR, Goulden N, Hoare Z et al. Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS): protocol for a mixed-methods, multicentre feasibility randomised controlled trial. Pilot and Feasibility Studies. 2022 Jun 11;8(1):123. doi: 10.1186/s40814-022-01073-5

Author

NEuRoMS Collective ; Topcu, Gogem ; Smith, Laura et al. / Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS) : protocol for a mixed-methods, multicentre feasibility randomised controlled trial. In: Pilot and Feasibility Studies. 2022 ; Vol. 8, No. 1. pp. 123.

RIS

TY - JOUR

T1 - Neuropsychological evaluation and rehabilitation in multiple sclerosis (NEuRoMS)

T2 - protocol for a mixed-methods, multicentre feasibility randomised controlled trial

AU - NEuRoMS Collective

AU - Topcu, Gogem

AU - Smith, Laura

AU - Mhizha-Murira, Jacqueline R

AU - Goulden, Nia

AU - Hoare, Zoë

AU - Drummond, Avril

AU - Fitzsimmons, Deborah

AU - Evangelou, Nikos

AU - Schmierer, Klaus

AU - Tallantyre, Emma C

AU - Leighton, Paul

AU - Allen-Philbey, Kimberley

AU - Stennett, Andrea

AU - Bradley, Paul

AU - Bale, Clare

AU - Turton, James

AU - das Nair, Roshan

N1 - © 2022. The Author(s).

PY - 2022/6/11

Y1 - 2022/6/11

N2 - BACKGROUND: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoing research has systematically developed a cognitive screening and management pathway (NEuRoMS) tailored for people with MS, involving a brief cognitive evaluation and rehabilitation intervention. The present study aims to assess the feasibility of delivering the pathway and will inform the design of a definitive randomised controlled trial (RCT) to investigate the clinical and cost-effectiveness of the intervention and eventually guide its clinical implementation.METHODS: The feasibility study is in three parts. Part 1 involves an observational study of those who receive screening and support for cognitive problems, using routinely collected clinical data. Part 2 is a two-arm, parallel group, multicentre, feasibility RCT with a nested fidelity evaluation. This part will evaluate the feasibility of undertaking a definitive trial comparing the NEuRoMS intervention plus usual care to usual care only, amongst people with MS with mild cognitive problems (n = 60). In part 3, semi-structured interviews will be undertaken with participants from part 2 (n = 25), clinicians (n = 9), and intervention providers (n = 3) involved in delivering the NEuRoMS cognitive screening and management pathway. MS participants will be recruited from outpatient clinics at three UK National Health Service hospitals.DISCUSSION: Timely screening and effective management of cognitive problems in MS are urgently needed due to the detrimental consequences of cognitive problems on people with MS, the healthcare system, and wider society. The NEuRoMS intervention is based on previous and extant literature and has been co-constructed with relevant stakeholders. If effective, the NEuRoMS pathway will facilitate timely identification and management of cognitive problems in people with MS.TRIAL REGISTRATION: ISRCTN11203922 . Prospectively registered on 09.02.2021.

AB - BACKGROUND: Cognitive problems affect up to 70% of people with multiple sclerosis (MS), which can negatively impact mood, ability to work, and quality of life. Addressing cognitive problems is a top 10 research priority for people with MS. Our ongoing research has systematically developed a cognitive screening and management pathway (NEuRoMS) tailored for people with MS, involving a brief cognitive evaluation and rehabilitation intervention. The present study aims to assess the feasibility of delivering the pathway and will inform the design of a definitive randomised controlled trial (RCT) to investigate the clinical and cost-effectiveness of the intervention and eventually guide its clinical implementation.METHODS: The feasibility study is in three parts. Part 1 involves an observational study of those who receive screening and support for cognitive problems, using routinely collected clinical data. Part 2 is a two-arm, parallel group, multicentre, feasibility RCT with a nested fidelity evaluation. This part will evaluate the feasibility of undertaking a definitive trial comparing the NEuRoMS intervention plus usual care to usual care only, amongst people with MS with mild cognitive problems (n = 60). In part 3, semi-structured interviews will be undertaken with participants from part 2 (n = 25), clinicians (n = 9), and intervention providers (n = 3) involved in delivering the NEuRoMS cognitive screening and management pathway. MS participants will be recruited from outpatient clinics at three UK National Health Service hospitals.DISCUSSION: Timely screening and effective management of cognitive problems in MS are urgently needed due to the detrimental consequences of cognitive problems on people with MS, the healthcare system, and wider society. The NEuRoMS intervention is based on previous and extant literature and has been co-constructed with relevant stakeholders. If effective, the NEuRoMS pathway will facilitate timely identification and management of cognitive problems in people with MS.TRIAL REGISTRATION: ISRCTN11203922 . Prospectively registered on 09.02.2021.

U2 - 10.1186/s40814-022-01073-5

DO - 10.1186/s40814-022-01073-5

M3 - Article

C2 - 35690797

VL - 8

SP - 123

JO - Pilot and Feasibility Studies

JF - Pilot and Feasibility Studies

SN - 2055-5784

IS - 1

ER -