Electronic versions

DOI

  • John A Sturgeon
    Stanford University
  • Meghan M Tieu
    Stanford University
  • Laura Jastrzab
    Stanford University
  • Rebecca McCue
    Stanford University
  • Vanisha Gandhi
    Stanford University
  • Sean C Mackey
    Stanford University

OBJECTIVE: A bidirectional relationship between working memory (WM) and acute pain has long been assumed, but equivocal evidence exists regarding this relationship. This study characterized the relationship between WM and acute pain processing in healthy individuals using an adapted Sternberg WM task.

DESIGN: Participants completed a Sternberg task while receiving noxious thermal stimulation. Participants received a pseudorandom presentation of four different temperatures (baseline temperatures and individually determined low-, medium-, and high-temperature stimuli) and four levels of Sternberg task difficulty (0-, 3-, 6-, and 9-letter strings).

SUBJECTS: Twenty-eight healthy participants were recruited from Stanford University and the surrounding community to complete this study.

RESULTS: A nonlinear interaction between intensity of thermal stimulation and difficulty of the Sternberg task was noted. Increased cognitive load from the Sternberg task resulted in increased perception of pain in low-intensity thermal stimulation but suppressed pain perception in high-intensity thermal stimulation. Thermal stimulation had no significant effect on participants' response time or accuracy on the Sternberg task regardless of intensity level.

CONCLUSIONS: Pain perception appears to decrease as a function of WM load only for sufficiently noxious stimuli. However, increasing noxious stimuli did not affect cognitive performance. These complex relationships may reflect a shared cognitive space that can become "overloaded" with input of multiple stimuli of sufficient intensity.

Keywords

  • Acute Pain/physiopathology, Adolescent, Adult, Cognition, Female, Hot Temperature/adverse effects, Humans, Male, Memory, Short-Term, Neuropsychological Tests, Nonlinear Dynamics, Pain Measurement, Pain Perception/physiology, Reaction Time/physiology, Young Adult
Original languageEnglish
Pages (from-to)1301-10
Number of pages10
JournalPain Medicine
Volume16
Issue number7
DOIs
Publication statusPublished - 15 Jul 2015
Externally publishedYes
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