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  • PLLA grafted gelatin

    Accepted author manuscript, 1 MB, PDF-document

    Embargo ends: 22/01/20

DOI

  • Du Beibei
    Fudan University, Shanghai, China
  • Fan Tiantang
    Fudan University, Shanghai, China
  • Li Jiafeng
    Fudan University, Shanghai, China
  • Zhang Qin
    Fudan University, Shanghai, China
  • Ye Wuyou
    Fudan University, Shanghai, China
  • Wenxin Wang
    University College Dublin
  • Hongyun Tai
  • Fan Zhongyong
    Fudan University, Shanghai, China
A series of poly(l‐lactide)‐grafted gelatin (Gel‐g‐PLLA) copolymers are synthesized by coupling the amino groups of gelatin with different molar masses and the carboxyl endgroup of poly(l‐lactide) in the presence of 1‐ethyl‐3‐(3‐dimethylaminopropyl)carbodiimide hydrochloride and N‐hydroxysuccinimide. Fourier transform infrared and nuclear magnetic resonance (1H NMR) data confirm the successful bonding between gelatin and PLLA. Self‐assembled micelles of copolymers are prepared by using the direct dissolution method. The size and micellar morphology are determined from dynamic light scattering as well as transmission electron microscopy measurements. Meanwhile, in vitro drug release reveals that Gel‐g‐PLLA micelles show excellent sustained‐release properties when used as the carrier of the anticancer drug paclitaxel. A burst release of about 70% is observed in the first 24 h. All these features, together with the outstanding biocompatibility, make Gel‐g‐PLLA micelles a promising drug carrier for cancer therapy.

Keywords

  • Drug delivery, Gelatin, Nanoparticles, Self-assembly, poly(l‐lactide)
Original languageEnglish
Article number1800528
JournalMacromolecular Chemistry and Physics
Volume220
Issue number5
Early online date22 Jan 2019
DOIs
Publication statusPublished - 5 Mar 2019
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