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Reduced parietal and visual cortical activation during global processing in Williams syndrome

Research output: Contribution to journal › Article › peer-review

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Reduced parietal and visual cortical activation during global processing in Williams syndrome. / Mobbs, Deab; Eckert, Mark A; Menon, Vinod et al.
In: Developmental Medicine and Child Neurology, Vol. 49, 2007, p. 433-438.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Mobbs, D, Eckert, MA, Menon, V, Mills, D, Korenberg, JR, Galaburda, A, Rose, F, Bellugi, U & Reiss, A 2007, 'Reduced parietal and visual cortical activation during global processing in Williams syndrome', Developmental Medicine and Child Neurology, vol. 49, pp. 433-438. https://doi.org/10.1111/j.1469-8749.2007.00433.x

APA

Mobbs, D., Eckert, M. A., Menon, V., Mills, D., Korenberg, J. R., Galaburda, A., Rose, F., Bellugi, U., & Reiss, A. (2007). Reduced parietal and visual cortical activation during global processing in Williams syndrome. Developmental Medicine and Child Neurology, 49, 433-438. https://doi.org/10.1111/j.1469-8749.2007.00433.x

CBE

Mobbs D, Eckert MA, Menon V, Mills D, Korenberg JR, Galaburda A, Rose F, Bellugi U, Reiss A. 2007. Reduced parietal and visual cortical activation during global processing in Williams syndrome. Developmental Medicine and Child Neurology. 49:433-438. https://doi.org/10.1111/j.1469-8749.2007.00433.x

MLA

Mobbs, Deab et al. "Reduced parietal and visual cortical activation during global processing in Williams syndrome". Developmental Medicine and Child Neurology. 2007, 49. 433-438. https://doi.org/10.1111/j.1469-8749.2007.00433.x

VancouverVancouver

Mobbs D, Eckert MA, Menon V, Mills D, Korenberg JR, Galaburda A et al. Reduced parietal and visual cortical activation during global processing in Williams syndrome. Developmental Medicine and Child Neurology. 2007;49:433-438. doi: 10.1111/j.1469-8749.2007.00433.x

Author

Mobbs, Deab ; Eckert, Mark A ; Menon, Vinod et al. / Reduced parietal and visual cortical activation during global processing in Williams syndrome. In: Developmental Medicine and Child Neurology. 2007 ; Vol. 49. pp. 433-438.

RIS

TY - JOUR

T1 - Reduced parietal and visual cortical activation during global processing in Williams syndrome

AU - Mobbs, Deab

AU - Eckert, Mark A

AU - Menon, Vinod

AU - Mills, Debra

AU - Korenberg, Julie R

AU - Galaburda, Albert

AU - Rose, Fred

AU - Bellugi, Ursula

AU - Reiss, Allan

PY - 2007

Y1 - 2007

N2 - Several lines of investigation suggest that individuals with Williams syndrome (WS), a neurodevelopmental disorder of well-characterized genetic etiology, have selective impairments in integrating local image elements into global configurations. We compared global processing abilities in 10 clinically and genetically diagnosed participants with WS (eight females, two males; mean age 31y 10mo [SD 9y 7mo], range 15y 5mo–48y 4mo) with a typically developed (TD) age- and sex-matched comparison group (seven females, one male; mean age 35y 2mo [SD 10y 10mo], range 24y–54y 7mo) using functional magnetic resonance imaging (fMRI). Behavioral data showed participants with WS to be significantly less accurate (p<0.042) together with a non-significant trend to be slower than the TD comparison group while performing the global processing task. fMRI data showed participants with WS to possess reduced activation in the visual and parietal cortices. Participants with WS also showed relatively normal activation in the ventral occipitotemporal cortex, but elevated activation in several posterior thalamic nuclei. These preliminary results largely confirm previous research findings and neural models implicating neurodevelopmental abnormalities in extended subcortical and cortical visual systems in WS, most notably dorsal-stream pathways.

AB - Several lines of investigation suggest that individuals with Williams syndrome (WS), a neurodevelopmental disorder of well-characterized genetic etiology, have selective impairments in integrating local image elements into global configurations. We compared global processing abilities in 10 clinically and genetically diagnosed participants with WS (eight females, two males; mean age 31y 10mo [SD 9y 7mo], range 15y 5mo–48y 4mo) with a typically developed (TD) age- and sex-matched comparison group (seven females, one male; mean age 35y 2mo [SD 10y 10mo], range 24y–54y 7mo) using functional magnetic resonance imaging (fMRI). Behavioral data showed participants with WS to be significantly less accurate (p<0.042) together with a non-significant trend to be slower than the TD comparison group while performing the global processing task. fMRI data showed participants with WS to possess reduced activation in the visual and parietal cortices. Participants with WS also showed relatively normal activation in the ventral occipitotemporal cortex, but elevated activation in several posterior thalamic nuclei. These preliminary results largely confirm previous research findings and neural models implicating neurodevelopmental abnormalities in extended subcortical and cortical visual systems in WS, most notably dorsal-stream pathways.

U2 - 10.1111/j.1469-8749.2007.00433.x

DO - 10.1111/j.1469-8749.2007.00433.x

M3 - Article

VL - 49

SP - 433

EP - 438

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

ER -