TY - JOUR

T1 - Refractory depression

T2 - mechanisms and evaluation of radically open dialectical behaviour therapy (RO-DBT) [REFRAMED]: protocol for randomised trial

AU - Lynch, Thomas R.

AU - Whalley, Ben

AU - Hempel, R J

AU - Byford, Sarah

AU - Clarke, P.

AU - Clarke, S.

AU - Kingdon, D.

AU - O'Mahen, Heather

AU - Russell, Ian T.

AU - Shearer, J

AU - Stanton, M

AU - Swales, M

AU - Watkins, Alan

AU - Remington, B

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/7/17

Y1 - 2015/7/17

N2 - INTRODUCTION: Only 30-40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression.METHODS AND ANALYSIS: REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective.ETHICS AND DISSEMINATION: The National Research Ethics Service (NRES) Committee South Central - Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146.TRIAL REGISTRATION NUMBER: ISRCTN85784627.

AB - INTRODUCTION: Only 30-40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression.METHODS AND ANALYSIS: REFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with treatment as usual (TAU). Our primary outcome measure is depressive symptoms 12 months after randomisation. We shall estimate the cost-effectiveness of RO-DBT by cost per quality-adjusted life year. Causal analyses will explore the mechanisms by which RO-DBT is effective.ETHICS AND DISSEMINATION: The National Research Ethics Service (NRES) Committee South Central - Southampton A first granted ethical approval on 20 June 2011, reference number 11/SC/0146.TRIAL REGISTRATION NUMBER: ISRCTN85784627.

KW - Behavior Therapy/economics

KW - Cost-Benefit Analysis

KW - Depression/drug therapy

KW - Drug Resistance

KW - Humans

KW - Quality-Adjusted Life Years

KW - Research Design

KW - Retreatment

U2 - 10.1136/bmjopen-2015-008857

DO - 10.1136/bmjopen-2015-008857

M3 - Article

C2 - 26187121

VL - 5

SP - e008857

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 7

ER -