Reproducible broadband measurement for cytoplasm capacitance of a biological cel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Electronic versions

  • X. Ma
    Lehigh University, Bethlehem, PA
  • X. Du
    Lehigh University, Bethlehem, PA
  • C.R. Multari
    Lehigh University, Bethlehem, PA
  • Y. Ning
    Lehigh University, Bethlehem, PA
  • X. Luo
    Lehigh University, Bethlehem, PA
  • V. Gholizadeh
    Lehigh University, Bethlehem, PA
  • Cristiano Palego
    Lehigh University, Bethlehem, PA
  • X. Cheng
    Lehigh University, Bethlehem, PA
  • J.C.M. Hwang
    Lehigh University, Bethlehem, PA
Using a coplanar waveguide with a series gap in conjunction with dielectrophoresis trapping, consecutive S-parameter measurements between 0.5 and 20 GHz were quickly performed with and without a Jurkat cell trapped to compensate for a relatively noisy and drifting background. Based on sixteen measurements repeated on eight live cells and eight dead cells, differences in both return and insertion losses show two distinct distributions indicating either return loss or insertion loss alone can be used to distinguish a live cell from a dead one. Further, since the frequency dependence is generally linear or absent, discrete-frequency measurement (as opposed to sweep-frequency measurement) of return or insertion loss may suffice. If proven statistically by a much larger number of cells, this should greatly speed up the measurement to facilitate its eventual field use.

Keywords

  • Insertion loss, Loss measurement, Capacitance, Coplanar waveguides, Transmission line measurements, Electrodes, Couplings
Original languageEnglish
Title of host publicationMicrowave Symposium (IMS), 2016 IEEE MTT-S International
DOIs
Publication statusPublished - 27 May 2016
Externally publishedYes
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