Rheumatoid cachexia and cardiovascular disease
Research output: Contribution to journal › Article › peer-review
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In: Clinical and Experimental Rheumatology, Vol. 27, No. 6, 13.02.2010, p. 985-8.
Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Rheumatoid cachexia and cardiovascular disease
AU - Metsios, G S
AU - Stavropoulos-Kalinoglou, A
AU - Panoulas, V F
AU - Sandoo, A
AU - Toms, T E
AU - Nevill, A M
AU - Koutedakis, Y
AU - Kitas, G D
PY - 2010/2/13
Y1 - 2010/2/13
N2 - OBJECTIVE: It has been frequently stated that rheumatoid cachexia (RC) associates with increased cardiovascular risk; however, no studies to date have investigated this. The aim of this study was to investigate the association of RC with multiple novel and classical cardiovascular disease (CVD) risk factors and the presence of established CVD in rheumatoid arthritis (RA).METHODS: A total of 34 RA patients with RC (RA+RC) were identified from a database of 400 RA patients using published RC criteria and compared to the remaining patients (RA-RC) who did not fulfil RC criteria. All patients were assessed for fat and fat-free mass, albumin (indicator of catabolism), disease activity/severity, novel and classical risk CVD factors and established CVD.RESULTS: Fat-free mass (kg) and albumin (g/L) were significantly decreased in RA+RC vs. RA-RC patients: 37.3(33.9-41.6) vs. 45.9(41.2-55.5), p<0.001 and 39.6 + or - 6.7 vs. 42.4 + or - 4.9, p=0.001). Percent body fat was not significantly different. No significant differences were detected in either the classical or novel CVD risk factors, 10-year CVD risk or the prevalence of established CVD.CONCLUSIONS: RC does not appear to be associated with worse CVD profile in RA patients, but this needs to be confirmed in prospective studies.
AB - OBJECTIVE: It has been frequently stated that rheumatoid cachexia (RC) associates with increased cardiovascular risk; however, no studies to date have investigated this. The aim of this study was to investigate the association of RC with multiple novel and classical cardiovascular disease (CVD) risk factors and the presence of established CVD in rheumatoid arthritis (RA).METHODS: A total of 34 RA patients with RC (RA+RC) were identified from a database of 400 RA patients using published RC criteria and compared to the remaining patients (RA-RC) who did not fulfil RC criteria. All patients were assessed for fat and fat-free mass, albumin (indicator of catabolism), disease activity/severity, novel and classical risk CVD factors and established CVD.RESULTS: Fat-free mass (kg) and albumin (g/L) were significantly decreased in RA+RC vs. RA-RC patients: 37.3(33.9-41.6) vs. 45.9(41.2-55.5), p<0.001 and 39.6 + or - 6.7 vs. 42.4 + or - 4.9, p=0.001). Percent body fat was not significantly different. No significant differences were detected in either the classical or novel CVD risk factors, 10-year CVD risk or the prevalence of established CVD.CONCLUSIONS: RC does not appear to be associated with worse CVD profile in RA patients, but this needs to be confirmed in prospective studies.
KW - Aged
KW - Aged, 80 and over
KW - Analysis of Variance
KW - Arthritis, Rheumatoid
KW - Body Mass Index
KW - Cachexia
KW - Cardiovascular Diseases
KW - Chi-Square Distribution
KW - Comorbidity
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Obesity
KW - Prevalence
KW - Prospective Studies
KW - Risk Factors
KW - Severity of Illness Index
KW - Statistics, Nonparametric
KW - Journal Article
M3 - Article
C2 - 20149317
VL - 27
SP - 985
EP - 988
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 6
ER -