TY - JOUR

T1 - Roadmap on Label-Free Super-resolution Imaging

AU - Astratov, Vasily

AU - Sahel, Yair

AU - Eldar, Yonina

AU - Huang, Luzhe

AU - Ozcan, Aydogan

AU - Wang, Zengbo (James )

AU - Zheludev, N.I.

AU - Zhao, Junxiang

AU - Burns, Zachary

AU - Liu, Zhaowei

AU - Narimanov, Evengii

AU - Goswami, Neha

AU - Popescu, Gabriel

AU - Pfitzner, Emanuael

AU - Kukura, Philipp

AU - Hsiao, Yi-Teng

AU - Hsieh, Chia-Lung

AU - Abbey, Brian

AU - Diaspro, Alberto

AU - LeGratiet, Aymeric

AU - Bianchini, Paulo

AU - Shaked, Natan T.

AU - Simon, Bertrand

AU - Verrier, Nicolas

AU - Debailleul, Matthieu

AU - Haeberle, Olivier

AU - Wang, Sheng

AU - Liu, Mengkun

AU - Bai, Yeran

AU - Cheng, Ji-Xin

AU - Karim,an, Behjat S.

AU - Fujita, Katsumasa

AU - Sinvani, Moshe

AU - Zalevsky, Zeev

AU - Li, Xiangping

AU - Huang, Guan-Ji

AU - Chu, Shi-Wei

AU - Tzang, Omer

AU - Smolyaninov, Igor I.

AU - Leonhardt, Ulf

AU - Sahebdivan, Sahar

AU - Hershkovitz, Dror

AU - Cheshnovsky, Ori

AU - Huttunen, Mikko J.

AU - Stanciu, Stefan G.

AU - Smolyaninova, Vera N.

AU - Wang, Zengbo (James )

AU - Luk'yanchuk, Boris

AU - Wu, Limin

AU - Maslov, Alexey V.

AU - Jin, Boya

AU - Simovski, Constantin R.

AU - Perrin, Stephane

AU - Montgomery, Paul

AU - Lecler, Sylvain

N1 - Engineering and Physical Sciences Research Council UK. Grant Numbers: EP/N00762X/1, EP/M009122/1 National Institutes of Health. Grant Numbers: R01GM129709, R01CA238191 National Science Foundation. Grant Numbers: 0939511, 1450962, 1353368 PHOTOMASS. Grant Number: 819593 EPSRC Leadership Fellowship. Grant Number: EP/T03419X/1

PY - 2023/12

Y1 - 2023/12

N2 - Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

AB - Label-free super-resolution (LFSR) imaging relies on light-scattering processes in nanoscale objects without a need for fluorescent (FL) staining required in super-resolved FL microscopy. The objectives of this Roadmap are to present a comprehensive vision of the developments, the state-of-the-art in this field, and to discuss the resolution boundaries and hurdles that need to be overcome to break the classical diffraction limit of the label-free imaging. The scope of this Roadmap spans from the advanced interference detection techniques, where the diffraction-limited lateral resolution is combined with unsurpassed axial and temporal resolution, to techniques with true lateral super-resolution capability that are based on understanding resolution as an information science problem, on using novel structured illumination, near-field scanning, and nonlinear optics approaches, and on designing superlenses based on nanoplasmonics, metamaterials, transformation optics, and microsphere-assisted approaches. To this end, this Roadmap brings under the same umbrella researchers from the physics and biomedical optics communities in which such studies have often been developing separately. The ultimate intent of this paper is to create a vision for the current and future developments of LFSR imaging based on its physical mechanisms and to create a great opening for the series of articles in this field.

U2 - 10.1002/lpor.202200029

DO - 10.1002/lpor.202200029

M3 - Article

VL - 17

JO - Laser & Photonics Reviews

JF - Laser & Photonics Reviews

SN - 1863-8899

IS - 12

M1 - 202200029

ER -