Supplementary Energy Increases Bone Formation during Arduous Military Training

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Supplementary Energy Increases Bone Formation during Arduous Military Training. / O'Leary, Thomas J; Walsh, Neil P; Casey, Anna et al.
In: Medicine and Science in Sports and Exercise, Vol. 53, No. 2, 01.02.2021, p. 394-403.

Research output: Contribution to journalArticlepeer-review

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O'Leary, TJ, Walsh, NP, Casey, A, Izard, RM, Tang, JCY, Fraser, WD & Greeves, JP 2021, 'Supplementary Energy Increases Bone Formation during Arduous Military Training', Medicine and Science in Sports and Exercise, vol. 53, no. 2, pp. 394-403. https://doi.org/10.1249/MSS.0000000000002473

APA

O'Leary, T. J., Walsh, N. P., Casey, A., Izard, R. M., Tang, J. C. Y., Fraser, W. D., & Greeves, J. P. (2021). Supplementary Energy Increases Bone Formation during Arduous Military Training. Medicine and Science in Sports and Exercise, 53(2), 394-403. https://doi.org/10.1249/MSS.0000000000002473

CBE

O'Leary TJ, Walsh NP, Casey A, Izard RM, Tang JCY, Fraser WD, Greeves JP. 2021. Supplementary Energy Increases Bone Formation during Arduous Military Training. Medicine and Science in Sports and Exercise. 53(2):394-403. https://doi.org/10.1249/MSS.0000000000002473

MLA

O'Leary, Thomas J et al. "Supplementary Energy Increases Bone Formation during Arduous Military Training". Medicine and Science in Sports and Exercise. 2021, 53(2). 394-403. https://doi.org/10.1249/MSS.0000000000002473

VancouverVancouver

O'Leary TJ, Walsh NP, Casey A, Izard RM, Tang JCY, Fraser WD et al. Supplementary Energy Increases Bone Formation during Arduous Military Training. Medicine and Science in Sports and Exercise. 2021 Feb 1;53(2):394-403. doi: 10.1249/MSS.0000000000002473

Author

O'Leary, Thomas J ; Walsh, Neil P ; Casey, Anna et al. / Supplementary Energy Increases Bone Formation during Arduous Military Training. In: Medicine and Science in Sports and Exercise. 2021 ; Vol. 53, No. 2. pp. 394-403.

RIS

TY - JOUR

T1 - Supplementary Energy Increases Bone Formation during Arduous Military Training

AU - O'Leary, Thomas J

AU - Walsh, Neil P

AU - Casey, Anna

AU - Izard, Rachel M

AU - Tang, Jonathan C Y

AU - Fraser, William D

AU - Greeves, Julie P

N1 - Copyright © 2020 by the American College of Sports Medicine.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - PURPOSE: This study aimed to investigate the effect of supplementary energy on bone formation and resorption during arduous military training in energy deficit.METHODS: Thirty male soldiers completed an 8-wk military combat course (mean ± SD, age = 25 ± 3 yr, height = 1.78 ± 0.05 m, body mass = 80.9 ± 7.7 kg). Participants received either the habitual diet (control group, n = 15) or an additional 5.1 MJ·d-1 to eliminate the energy deficit (supplemented group, n = 15). Circulating markers of bone formation and resorption, and reproductive, thyroid, and metabolic status, were measured at baseline and weeks 6 and 8 of training.RESULTS: Bone-specific alkaline phosphatase decreased in controls (-4.4 ± 1.9 μg·L-1) and increased in the supplemented group (16.0 ± 6.6 μg·L-1), between baseline and week 8 (P < 0.001). Procollagen type 1 N-terminal propeptide increased between baseline and week 6 for both groups (5.6 ± 8.1 μg·L-1, P = 0.005). Beta carboxy-terminal cross-linking telopeptide of type 1 collagen decreased between baseline and week 8 for both groups (-0.16 ± 0.20 μg·L-1, P < 0.001). Prolactin increased from baseline to week 8 for the supplemented group (148 ± 151 IU·L-1, P = 0.041). The increase in adiponectin from baseline to week 8 was higher in controls (4.3 ± 1.8 mg·L-1, P < 0.001) than that in the supplemented group (1.4 ± 1.0 mg·L-1, P < 0.001). Insulin-like growth factor binding protein-3 was lower at week 8 than baseline for controls (-461 ± 395 ng·mL-1, P < 0.001).CONCLUSION: The increase in bone-specific alkaline phosphatase, a marker of bone formation, with supplementation supports a role of energy in osteoblastic activity; the implications for skeletal adaptation and stress fracture risk are unclear. The mechanism is likely through protecting markers of metabolic, but not reproductive or thyroid, function.

AB - PURPOSE: This study aimed to investigate the effect of supplementary energy on bone formation and resorption during arduous military training in energy deficit.METHODS: Thirty male soldiers completed an 8-wk military combat course (mean ± SD, age = 25 ± 3 yr, height = 1.78 ± 0.05 m, body mass = 80.9 ± 7.7 kg). Participants received either the habitual diet (control group, n = 15) or an additional 5.1 MJ·d-1 to eliminate the energy deficit (supplemented group, n = 15). Circulating markers of bone formation and resorption, and reproductive, thyroid, and metabolic status, were measured at baseline and weeks 6 and 8 of training.RESULTS: Bone-specific alkaline phosphatase decreased in controls (-4.4 ± 1.9 μg·L-1) and increased in the supplemented group (16.0 ± 6.6 μg·L-1), between baseline and week 8 (P < 0.001). Procollagen type 1 N-terminal propeptide increased between baseline and week 6 for both groups (5.6 ± 8.1 μg·L-1, P = 0.005). Beta carboxy-terminal cross-linking telopeptide of type 1 collagen decreased between baseline and week 8 for both groups (-0.16 ± 0.20 μg·L-1, P < 0.001). Prolactin increased from baseline to week 8 for the supplemented group (148 ± 151 IU·L-1, P = 0.041). The increase in adiponectin from baseline to week 8 was higher in controls (4.3 ± 1.8 mg·L-1, P < 0.001) than that in the supplemented group (1.4 ± 1.0 mg·L-1, P < 0.001). Insulin-like growth factor binding protein-3 was lower at week 8 than baseline for controls (-461 ± 395 ng·mL-1, P < 0.001).CONCLUSION: The increase in bone-specific alkaline phosphatase, a marker of bone formation, with supplementation supports a role of energy in osteoblastic activity; the implications for skeletal adaptation and stress fracture risk are unclear. The mechanism is likely through protecting markers of metabolic, but not reproductive or thyroid, function.

U2 - 10.1249/MSS.0000000000002473

DO - 10.1249/MSS.0000000000002473

M3 - Article

C2 - 32701874

VL - 53

SP - 394

EP - 403

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 2

ER -