Synthesis of wax esters and related trehalose esters from Mycobacterium avium and other mycobacteria
Research output: Contribution to journal › Article › peer-review
Electronic versions
DOI
The synthesis of mycobacterial mycolic acid related wax esters and of their trehalose di- and mono-esters is described. The trehalose dimycolates (TDMs) synthesised activated bone marrow derived dendritic cells (BMDCs) in vitro more strongly than trehalose dibehenate or the trehalose monomycolates (TMMs). The inflammatory effects were similar to those of TDM from either a synthetic keto- or methoxy-mycolic acid, but somewhat stronger than those of a TDM from an α-mycolic acid. In vivo, the effects of one wax ester TDM were similar to those of the methoxy-MA and α-mycolic acid TDMs and trehalose dibehenate.
| Original language | English |
|---|---|
| Pages (from-to) | 3863-3876 |
| Number of pages | 13 |
| Journal | Tetrahedron |
| Volume | 72 |
| Issue number | 27-28 |
| Early online date | 6 May 2016 |
| DOIs | |
| Publication status | Published - 7 Jul 2016 |