Many children with Intellectual and Developmental Disabilities (IDD) have considerable difficulty learning basic reading skills. Increasing evidence suggests individuals with IDD may benefit from instruction incorporating components of reading found to be effective for typically developing children. However, little research into reading instruction for children with IDD has incorporated these components. There is evidence for the efficacy of Headsprout® Early Reading program for typically developing children, and emerging evidence suggesting that children with autism can benefit from the program. The current study investigated the accessibility of Headsprout® Early Reading for children with IDD, and whether there were any measurable effects of the program on important early reading and language skills. Six children aged between 7 and 14 years with mild to moderate IDD completed the program, and all made measurable improvements across reading measures, demonstrating children with mild to moderate IDD can access (i.e., progress through and benefit from) the program.