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  • Malihe Moghadami
    Ferdowsi University of Mashhad
  • Sahar Moghimi
    Ferdowsi University of Mashhad
  • Ali Moghimi
    Ferdowsi University of Mashhad
  • Gholam Reza Malekzadeh
    Ferdowsi University of Mashhad
  • Javad Salehi Fadardi
Alzheimer’s disease (AD) is a neurodegenerative disorder that occurs many years before the first clinical symptoms. Finding more exact, significant, and valuable criteria or indices for the diagnosis of the mild form of Alzheimer’s disease is very important for clinical and research purposes. Electroencephalography (EEG) and eye tracking biomarkers would provide noninvasive tools for the early detection of AD. Due to the advantages of EEG and eye tracking, in this study, we employed them simultaneously to conduct research on the mild AD. For this purpose, 19 patients with mild AD were compared with 19 gender- and age-matched normal subjects who did not have any history of cognitive or neurological disorders. EEG and eye-tracking data were concurrently collected in both groups in a fixation task. Our results revealed that the total fixation duration was significantly shorter for the AD patients, but their fixation frequency was more than that of the controls. In addition, increased theta power and decreased alpha power were observed in the AD group. Interestingly, there was a statistically significant correlation between fixation frequency and alpha power in the parietal area in the control group. However, this connection was not statistically significant in the AD group. The findings also indicated an elevated coherence in the AD patients in the parieto-occipital area. It is assumed that the AD patients might use the neural compensational processes for the fixation state. This study provides evidence for the simultaneously EEG and eye-tracking changes in the areas, which are involved in the control of the fixational eye movements.


  • Neurology, Clinical Neurology, General Medicine
Original languageEnglish
Pages (from-to)211-220
Number of pages10
JournalClinical EEG and Neuroscience
Issue number3
Early online date16 Jun 2020
Publication statusPublished - 1 Jul 2020
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