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DOI

  • Aamer Sandoo
    Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, UK.University of Birmingham
  • Athanassios D Protogerou
  • James Hodson
  • Jacqueline P Smith
  • Evi Zampeli
  • Petros P Sfikakis
  • George D Kitas

INTRODUCTION: Evidence indicates that rheumatoid arthritis (RA) patients have increased susceptibility to myocardial ischaemia that contributes to myocardial infarction. The subendocardial viability ratio (SEVR) can be measured using pulse wave analysis and reflects myocardial oxygen supply and demand. The objective of the present study was to examine specific predictors of SEVR in RA patients, with a specific focus on inflammation and classical cardiovascular disease (CVD) risk factors.

METHODS: Two patient cohorts were included in the study; a primary cohort consisting of 220 RA patients and a validation cohort of 127 RA patients. All patients underwent assessment of SEVR using pulse wave analysis. Thirty-one patients from the primary cohort who were about to start anti-inflammatory treatment were prospectively examined for SEVR at pretreatment baseline and 2 weeks, 3 months and 1 year following treatment. Systemic markers of disease activity and classical CVD risk factors were assessed in all patients.

RESULTS: The SEVR (mean ± standard deviation) for RA in the primary cohort was 148 ± 27 and in the validation cohort was 142 ± 25. Regression analyses revealed that all parameters of RA disease activity were associated with SEVR, along with gender, blood pressure and heart rate. These findings were the same in the validation cohort. Analysis of longitudinal data showed that C-reactive protein (P < 0.001), erythrocyte sedimentation rate (P < 0.005), Disease Activity Score in 28 joints (P < 0.001), mean blood pressure (P < 0.005) and augmentation index (P < 0.001) were significantly reduced after commencing anti-TNFα treatment. Increasing C-reactive protein was found to be associated with a reduction in SEVR (P = 0.02) and an increase in augmentation index (P = 0.001).

CONCLUSION: The present findings reveal that the SEVR is associated with markers of disease activity as well as highly prevalent classical CVD risk factors in RA, such as high blood pressure and diabetes. Further prospective studies are required to determine whether the SEVR predicts future cardiac events in RA.

Keywords

  • Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Antihypertensive Agents, Antirheumatic Agents, Arthritis, Rheumatoid, Autonomic Nervous System, Blood Sedimentation, C-Reactive Protein, Cardiovascular Diseases, Cross-Sectional Studies, Endocardium, Female, Heart Rate, Humans, Inflammation, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Pulse Wave Analysis, Regression Analysis, Risk Factors, Survival Analysis, Journal Article, Research Support, Non-U.S. Gov't
Original languageEnglish
Pages (from-to)R258
JournalArthritis Research & Therapy
Volume14
Issue number6
DOIs
Publication statusPublished - 28 Nov 2012
Externally publishedYes
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