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The Role of Nitroreductases in Resistance to Nitroimidazoles

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The Role of Nitroreductases in Resistance to Nitroimidazoles. / Thomas, Carol; Gwenin, Christopher D.
In: Biology, Vol. 10, No. 5, 01.05.2021.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Thomas, C & Gwenin, CD 2021, 'The Role of Nitroreductases in Resistance to Nitroimidazoles', Biology, vol. 10, no. 5. https://doi.org/10.3390/biology10050388

APA

Thomas, C., & Gwenin, C. D. (2021). The Role of Nitroreductases in Resistance to Nitroimidazoles. Biology, 10(5). https://doi.org/10.3390/biology10050388

CBE

Thomas C, Gwenin CD. 2021. The Role of Nitroreductases in Resistance to Nitroimidazoles. Biology. 10(5). https://doi.org/10.3390/biology10050388

MLA

Thomas, Carol and Christopher D Gwenin. "The Role of Nitroreductases in Resistance to Nitroimidazoles". Biology. 2021. 10(5). https://doi.org/10.3390/biology10050388

VancouverVancouver

Thomas C, Gwenin CD. The Role of Nitroreductases in Resistance to Nitroimidazoles. Biology. 2021 May 1;10(5). doi: 10.3390/biology10050388

Author

Thomas, Carol ; Gwenin, Christopher D. / The Role of Nitroreductases in Resistance to Nitroimidazoles. In: Biology. 2021 ; Vol. 10, No. 5.

RIS

TY - JOUR

T1 - The Role of Nitroreductases in Resistance to Nitroimidazoles

AU - Thomas, Carol

AU - Gwenin, Christopher D

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of activity against anaerobic Gram-negative and Gram-positive bacteria. The role of nitroreductases is to activate the antimicrobial by reducing the nitro group. A decrease in the activity of nitroreductases is associated with resistance. This review will discuss the resistance mechanisms of different disease organisms, including , and , and how these impact the effectiveness of specific nitroimidazoles. Perspectives in the field of nitroimidazole drug development are also summarised.

AB - Antimicrobial resistance is a major challenge facing modern medicine, with an estimated 700,000 people dying annually and a global cost in excess of $100 trillion. This has led to an increased need to develop new, effective treatments. This review focuses on nitroimidazoles, which have seen a resurgence in interest due to their broad spectrum of activity against anaerobic Gram-negative and Gram-positive bacteria. The role of nitroreductases is to activate the antimicrobial by reducing the nitro group. A decrease in the activity of nitroreductases is associated with resistance. This review will discuss the resistance mechanisms of different disease organisms, including , and , and how these impact the effectiveness of specific nitroimidazoles. Perspectives in the field of nitroimidazole drug development are also summarised.

KW - antimicrobial resistance

KW - metronidazole

KW - mitromidazole

KW - nim genes

KW - nitroreductases

U2 - 10.3390/biology10050388

DO - 10.3390/biology10050388

M3 - Article

C2 - 34062712

VL - 10

JO - Biology

JF - Biology

SN - 2079-7737

IS - 5

ER -