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Thiol modified mycolic acids

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Thiol modified mycolic acids. / Balogun, Mohammed O; Huws, Enlli H; Sirhan, Muthana M et al.
In: Chemistry and Physics of Lipids, Vol. 172-173, No. July-August, 07.2013, p. 40-57.

Research output: Contribution to journal › Article › peer-review

HarvardHarvard

Balogun, MO, Huws, EH, Sirhan, MM, Saleh, AD, Al Dulayymi, JR, Pilcher, L, Verschoor, JA & Baird, MS 2013, 'Thiol modified mycolic acids', Chemistry and Physics of Lipids, vol. 172-173, no. July-August, pp. 40-57. https://doi.org/10.1016/j.chemphyslip.2013.03.004

APA

Balogun, M. O., Huws, E. H., Sirhan, M. M., Saleh, A. D., Al Dulayymi, J. R., Pilcher, L., Verschoor, J. A., & Baird, M. S. (2013). Thiol modified mycolic acids. Chemistry and Physics of Lipids, 172-173(July-August), 40-57. https://doi.org/10.1016/j.chemphyslip.2013.03.004

CBE

Balogun MO, Huws EH, Sirhan MM, Saleh AD, Al Dulayymi JR, Pilcher L, Verschoor JA, Baird MS. 2013. Thiol modified mycolic acids. Chemistry and Physics of Lipids. 172-173(July-August):40-57. https://doi.org/10.1016/j.chemphyslip.2013.03.004

MLA

Balogun, Mohammed O et al. "Thiol modified mycolic acids". Chemistry and Physics of Lipids. 2013, 172-173(July-August). 40-57. https://doi.org/10.1016/j.chemphyslip.2013.03.004

VancouverVancouver

Balogun MO, Huws EH, Sirhan MM, Saleh AD, Al Dulayymi JR, Pilcher L et al. Thiol modified mycolic acids. Chemistry and Physics of Lipids. 2013 Jul;172-173(July-August):40-57. Epub 2013 Apr 18. doi: 10.1016/j.chemphyslip.2013.03.004

Author

Balogun, Mohammed O ; Huws, Enlli H ; Sirhan, Muthana M et al. / Thiol modified mycolic acids. In: Chemistry and Physics of Lipids. 2013 ; Vol. 172-173, No. July-August. pp. 40-57.

RIS

TY - JOUR

T1 - Thiol modified mycolic acids

AU - Balogun, Mohammed O

AU - Huws, Enlli H

AU - Sirhan, Muthana M

AU - Saleh, Ahmed D

AU - Al Dulayymi, Juma'a R

AU - Pilcher, Lynne

AU - Verschoor, Jan A

AU - Baird, Mark S

N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/7

Y1 - 2013/7

N2 - Patient serum antibodies to mycolic acids have the potential to be surrogate markers of active tuberculosis (TB) when they can be distinguished from the ubiquitously present cross-reactive antibodies to cholesterol. Mycolic acids are known to interact more strongly with antibodies present in the serum of patients with active TB than in patients with latent TB or no TB. Examples of single stereoisomers of mycolic acids with chain lengths corresponding to major homologues of those present in Mycobacterium tuberculosis have now been synthesised with a sulfur substituent on the terminal position of the α-chain; initial studies have established that one of these binds to a gold electrode surface, offering the potential to develop second generation sensors for diagnostic patient antibody detection.

AB - Patient serum antibodies to mycolic acids have the potential to be surrogate markers of active tuberculosis (TB) when they can be distinguished from the ubiquitously present cross-reactive antibodies to cholesterol. Mycolic acids are known to interact more strongly with antibodies present in the serum of patients with active TB than in patients with latent TB or no TB. Examples of single stereoisomers of mycolic acids with chain lengths corresponding to major homologues of those present in Mycobacterium tuberculosis have now been synthesised with a sulfur substituent on the terminal position of the α-chain; initial studies have established that one of these binds to a gold electrode surface, offering the potential to develop second generation sensors for diagnostic patient antibody detection.

KW - Antibodies/immunology

KW - Electrochemical Techniques

KW - Electrodes

KW - Humans

KW - Mycolic Acids/chemical synthesis

KW - Stereoisomerism

KW - Sulfhydryl Compounds/chemistry

KW - Tuberculosis/immunology

U2 - 10.1016/j.chemphyslip.2013.03.004

DO - 10.1016/j.chemphyslip.2013.03.004

M3 - Article

C2 - 23603063

VL - 172-173

SP - 40

EP - 57

JO - Chemistry and Physics of Lipids

JF - Chemistry and Physics of Lipids

SN - 0009-3084

IS - July-August

ER -