Electronic versions



The ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) family proteins are evolutionarily conserved serine/threonine kinases best known for their roles in mediating the DNA damage response. Upon activation, ATM/ATR phosphorylate numerous targets to stabilize stalled replication forks, repair damaged DNA, and inhibit cell cycle progression to ensure survival of the cell and safeguard integrity of the genome. Intriguingly, separation of function alleles of the human ATM and MEC1, the budding yeast ATM/ATR, were shown to confer widespread protein aggregation and acute sensitivity to different types of proteotoxic agents including heavy metal, amino acid analogue, and an aggregation-prone peptide derived from the Huntington's disease protein. Further analyses unveiled that ATM and Mec1 promote resistance to perturbation in protein homeostasis via a mechanism distinct from the DNA damage response. In this minireview, we summarize the key findings and discuss ATM/ATR as a multifaceted signalling protein capable of mediating cellular response to both DNA and protein damage.


  • Ataxia Telangiectasia Mutated Proteins/genetics, DNA Damage, DNA Repair, DNA Replication, Humans, Oxidative Stress, Proteostasis, Signal Transduction
Original languageEnglish
Pages (from-to)657-661
JournalCurrent Genetics
Issue number3
Early online date5 Jan 2019
Publication statusPublished - Jun 2019

Total downloads

No data available
View graph of relations