Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans

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  • Andrew W D'Souza
    Western University, Ontario
  • Sarah L Hissen
    Institute for Exercise and Environmental Medicine
  • Kazumasa Manabe
    Institute for Exercise and Environmental Medicine
  • Ryosuke Takeda
    Institute for Exercise and Environmental Medicine
  • Takuro Washio
    Institute for Exercise and Environmental Medicine
  • Geoff B Coombs
    Western University, Ontario
  • Belinda Sanchez
    Institute for Exercise and Environmental Medicine
  • Qi Fu
    Institute for Exercise and Environmental Medicine
  • J Kevin Shoemaker
    Western University, Ontario

Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex impact blood pressure regulation, how these factors affect the central and peripheral arcs of the baroreflex remains unclear. In 27 young [25 (SD 3) yr] males (YM; n = 14) and females (YF; n = 13) and 23 older [71 (SD 5) yr] males (OM; n = 11) and females (OF; n = 12), femoral artery blood flow, blood pressure, and MSNA were recorded for 10 min of supine rest. Sympathetic baroreflex sensitivity (i.e., central arc) was quantified as the relationship between diastolic blood pressure and MSNA burst incidence. Signal averaging was used to determine sympathetic vascular transduction into leg vascular conductance (LVC) for 12 cardiac cycles following MSNA bursts (i.e., peripheral arc). Older adults demonstrated attenuated sympathetic transduction into LVC (both P < 0.001) following MSNA bursts, and smaller increases in sympathetic transduction as a function of MSNA burst size and firing pattern compared with young adults (range, P = 0.004-0.032). YM (r2 = 0.36; P = 0.032) and OM (r2 = 0.51; P = 0.014) exhibited an inverse relationship between the central and peripheral arcs of the baroreflex, whereas females did not (YF, r2 = 0.03, P = 0.621; OF, r2 = 0.06, P = 0.445). MSNA burst incidence was inversely related to sympathetic transduction in YM and OF (range, P = 0.03-0.046) but not in YF or OM (range, P = 0.360-0.603). These data indicate that age is associated with attenuated sympathetic vascular transduction, whereas age- and sex-specific changes are present in the relationship between the central and peripheral arcs of the baroreflex regulation of blood pressure.NEW & NOTEWORTHY Sympathetic vascular transduction is attenuated in older compared with young adults, regardless of biological sex. Males, but not females (regardless of age), demonstrate an inverse relationship between central (sympathetic baroreflex sensitivity) and peripheral (sympathetic vascular transduction) components of the baroreflex arc. Young males and older females exhibit an inverse relationship between resting sympathetic outflow and sympathetic vascular transduction. Our results indicate that age and sex exert independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.

Allweddeiriau

Iaith wreiddiolSaesneg
Tudalennau (o-i)H917-H932
CyfnodolynAmerican Journal of Physiology - Heart and Circulatory Physiology
Cyfrol325
Rhif y cyfnodolyn4
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Hyd 2023
Cyhoeddwyd yn allanolIe
Gweld graff cysylltiadau