Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans

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Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans. / D'Souza, Andrew W; Hissen, Sarah L; Manabe, Kazumasa et al.
Yn: American Journal of Physiology - Heart and Circulatory Physiology, Cyfrol 325, Rhif 4, 01.10.2023, t. H917-H932.

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

HarvardHarvard

D'Souza, AW, Hissen, SL, Manabe, K, Takeda, R, Washio, T, Coombs, GB, Sanchez, B, Fu, Q & Shoemaker, JK 2023, 'Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans', American Journal of Physiology - Heart and Circulatory Physiology, cyfrol. 325, rhif 4, tt. H917-H932. https://doi.org/10.1152/ajpheart.00301.2023

APA

D'Souza, A. W., Hissen, S. L., Manabe, K., Takeda, R., Washio, T., Coombs, G. B., Sanchez, B., Fu, Q., & Shoemaker, J. K. (2023). Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans. American Journal of Physiology - Heart and Circulatory Physiology, 325(4), H917-H932. https://doi.org/10.1152/ajpheart.00301.2023

CBE

D'Souza AW, Hissen SL, Manabe K, Takeda R, Washio T, Coombs GB, Sanchez B, Fu Q, Shoemaker JK. 2023. Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans. American Journal of Physiology - Heart and Circulatory Physiology. 325(4):H917-H932. https://doi.org/10.1152/ajpheart.00301.2023

MLA

D'Souza, Andrew W et al. "Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans". American Journal of Physiology - Heart and Circulatory Physiology. 2023, 325(4). H917-H932. https://doi.org/10.1152/ajpheart.00301.2023

VancouverVancouver

D'Souza AW, Hissen SL, Manabe K, Takeda R, Washio T, Coombs GB et al. Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans. American Journal of Physiology - Heart and Circulatory Physiology. 2023 Hyd 1;325(4):H917-H932. doi: 10.1152/ajpheart.00301.2023

Author

D'Souza, Andrew W ; Hissen, Sarah L ; Manabe, Kazumasa et al. / Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans. Yn: American Journal of Physiology - Heart and Circulatory Physiology. 2023 ; Cyfrol 325, Rhif 4. tt. H917-H932.

RIS

TY - JOUR

T1 - Age- and sex-related differences in sympathetic vascular transduction and neurohemodynamic balance in humans

AU - D'Souza, Andrew W

AU - Hissen, Sarah L

AU - Manabe, Kazumasa

AU - Takeda, Ryosuke

AU - Washio, Takuro

AU - Coombs, Geoff B

AU - Sanchez, Belinda

AU - Fu, Qi

AU - Shoemaker, J Kevin

PY - 2023/10/1

Y1 - 2023/10/1

N2 - Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex impact blood pressure regulation, how these factors affect the central and peripheral arcs of the baroreflex remains unclear. In 27 young [25 (SD 3) yr] males (YM; n = 14) and females (YF; n = 13) and 23 older [71 (SD 5) yr] males (OM; n = 11) and females (OF; n = 12), femoral artery blood flow, blood pressure, and MSNA were recorded for 10 min of supine rest. Sympathetic baroreflex sensitivity (i.e., central arc) was quantified as the relationship between diastolic blood pressure and MSNA burst incidence. Signal averaging was used to determine sympathetic vascular transduction into leg vascular conductance (LVC) for 12 cardiac cycles following MSNA bursts (i.e., peripheral arc). Older adults demonstrated attenuated sympathetic transduction into LVC (both P < 0.001) following MSNA bursts, and smaller increases in sympathetic transduction as a function of MSNA burst size and firing pattern compared with young adults (range, P = 0.004-0.032). YM (r2 = 0.36; P = 0.032) and OM (r2 = 0.51; P = 0.014) exhibited an inverse relationship between the central and peripheral arcs of the baroreflex, whereas females did not (YF, r2 = 0.03, P = 0.621; OF, r2 = 0.06, P = 0.445). MSNA burst incidence was inversely related to sympathetic transduction in YM and OF (range, P = 0.03-0.046) but not in YF or OM (range, P = 0.360-0.603). These data indicate that age is associated with attenuated sympathetic vascular transduction, whereas age- and sex-specific changes are present in the relationship between the central and peripheral arcs of the baroreflex regulation of blood pressure.NEW & NOTEWORTHY Sympathetic vascular transduction is attenuated in older compared with young adults, regardless of biological sex. Males, but not females (regardless of age), demonstrate an inverse relationship between central (sympathetic baroreflex sensitivity) and peripheral (sympathetic vascular transduction) components of the baroreflex arc. Young males and older females exhibit an inverse relationship between resting sympathetic outflow and sympathetic vascular transduction. Our results indicate that age and sex exert independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.

AB - Bursts of muscle sympathetic nerve activity (MSNA) and the ensuing vasoconstriction are pivotal determinants of beat-by-beat blood pressure regulation. Although age and sex impact blood pressure regulation, how these factors affect the central and peripheral arcs of the baroreflex remains unclear. In 27 young [25 (SD 3) yr] males (YM; n = 14) and females (YF; n = 13) and 23 older [71 (SD 5) yr] males (OM; n = 11) and females (OF; n = 12), femoral artery blood flow, blood pressure, and MSNA were recorded for 10 min of supine rest. Sympathetic baroreflex sensitivity (i.e., central arc) was quantified as the relationship between diastolic blood pressure and MSNA burst incidence. Signal averaging was used to determine sympathetic vascular transduction into leg vascular conductance (LVC) for 12 cardiac cycles following MSNA bursts (i.e., peripheral arc). Older adults demonstrated attenuated sympathetic transduction into LVC (both P < 0.001) following MSNA bursts, and smaller increases in sympathetic transduction as a function of MSNA burst size and firing pattern compared with young adults (range, P = 0.004-0.032). YM (r2 = 0.36; P = 0.032) and OM (r2 = 0.51; P = 0.014) exhibited an inverse relationship between the central and peripheral arcs of the baroreflex, whereas females did not (YF, r2 = 0.03, P = 0.621; OF, r2 = 0.06, P = 0.445). MSNA burst incidence was inversely related to sympathetic transduction in YM and OF (range, P = 0.03-0.046) but not in YF or OM (range, P = 0.360-0.603). These data indicate that age is associated with attenuated sympathetic vascular transduction, whereas age- and sex-specific changes are present in the relationship between the central and peripheral arcs of the baroreflex regulation of blood pressure.NEW & NOTEWORTHY Sympathetic vascular transduction is attenuated in older compared with young adults, regardless of biological sex. Males, but not females (regardless of age), demonstrate an inverse relationship between central (sympathetic baroreflex sensitivity) and peripheral (sympathetic vascular transduction) components of the baroreflex arc. Young males and older females exhibit an inverse relationship between resting sympathetic outflow and sympathetic vascular transduction. Our results indicate that age and sex exert independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.

KW - Male

KW - Female

KW - Young Adult

KW - Humans

KW - Aged

KW - Blood Pressure

KW - Baroreflex

KW - Femoral Artery

KW - Heart

KW - Lower Extremity

U2 - 10.1152/ajpheart.00301.2023

DO - 10.1152/ajpheart.00301.2023

M3 - Article

C2 - 37594483

VL - 325

SP - H917-H932

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 4

ER -