Cyclic guanidine containing amino acids that promote glucocerebrosidase
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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Yn: Tetrahedron, Cyfrol 123, 132959, 24.09.2022.
Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
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T1 - Cyclic guanidine containing amino acids that promote glucocerebrosidase
AU - Al-Taie, Zahraa S.
AU - Bartholomew, Barbara
AU - Coles, Simon J.
AU - Evans, Daniel M.
AU - Hollinshead, Jackie
AU - Jones, Leigh F.
AU - Kraehenbuehl, Rolf
AU - Murphy, Patrick J.
AU - Nash, Robert J.
AU - Penkova, Yana B.
AU - Tizzard, Graham J.
PY - 2022/9/24
Y1 - 2022/9/24
N2 - Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.
AB - Novel cyclic guanidine containing amino acids (S)-1, 2 and 3 were prepared from l-serine 5. (S)-2-Imino-3-methylimidazolidine-4-carboxylic acid hydrochloride salt 2. HCl and (3S, 6S)-3,6-bis(hydroxymethyl)-1,4-dimethylpiperazine-2,5-dione 15 showed in vitro promotion of the enzyme glucocerebrosidase.
KW - Cyclic guanidines
KW - Glycosidase inhibitors
KW - Glycosidase promoters
KW - -methylation
U2 - 10.1016/j.tet.2022.132959
DO - 10.1016/j.tet.2022.132959
M3 - Article
VL - 123
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
M1 - 132959
ER -